Defining Phenotypes of Movement Disorders :Parkinson’s Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.

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Brief Title

Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.

Official Title

Defining Cognitive and Motor Phenotypes of Parkinson's Disease (PD) With Magnetoencephalography

Brief Summary

      Investigators hypothesize that there are specific characteristic of each cognitive and motor
      condition that can be defined using brains scans.
    

Detailed Description

      Specific Aim 1: Determine which features of resting Magnetoencephalography (MEG) brain
      activity most sensitively discriminate between PD with normal cognition, PD with mild
      cognitive impairment (MCI), and PD dementia (PDD). Investigators predict that frontal network
      slowing and connectivity will discriminate between normal cognition and MCI while
      visuospatial network involvement will distinguish the PDD group.

      Specific Aim 2: Determine which features of resting MEG brain activity most sensitively
      discriminate PDD from Alzheimer's Disease. Investigators predict that PDD will be
      distinguished from Alzheimer's (AD) on the basis of increased network connectivity,
      particularly in frontal and visuospatial networks.

      Specific Aim 3 Investigate how resting state MEG activity correlates with task related brain
      activity. Investigators predict that resting state slowing will be associated with decreased
      task related brain activity.

      Specific Aim 4: Determine which features of resting MEG brain activity most sensitively
      discriminate between motor subtypes of PD and also other relevant clinical populations
      (essential tremor and Parkinson plus syndromes). Investigators predict that frontal and
      parietal slowing and connectivity will discriminate PD from related conditions and that
      patterns of motor cortex connectivity and activity will differentiate among PD motor
      phenotypes.
    


Study Type

Observational


Primary Outcome

Focal oscillatory activity

Secondary Outcome

 Spectral coherence:

Condition

Essential Tremor



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

81

Start Date

November 2013

Completion Date

May 2014

Primary Completion Date

May 2014

Eligibility Criteria

        Inclusion Criteria:

          -  All subjects will be age 40 or older,

          -  Be on stable medications for at least 30 days

          -  Montreal Cognitive Assessment (MOCA) of 26 or higher

          -  Scores within 1.5 standard deviations of age-matched norms for all neuropsychological
             tests

          -  Parkinson's Plus Disorders (PD) will be defined using United Kingdom (UK) Brain Bank
             Criteria.

          -  PD dementia (PDD) will be defined using the Movement Disorder Task Force 2007 criteria
             and supported by scores less than 1.5 standard deviations of age-matched norms in at
             least two domains.

          -  Probable Alzheimer's Disease (AD) will be defined using the National Institute on
             Aging-Alzheimer Association 2011 guidelines.

          -  Parkinson's Plus Disorders (PD) with mild cognitive impairment (MCI) will be defined
             by history, MOCA of 21 or higher, at least one score less than 1.5 standard deviations
             of age-matched norms, and cannot meet diagnostic criteria for PDD.

          -  Essential tremor and Parkinson plus syndromes (multiple systems atrophy, corticobasal
             degeneration, progressive supranuclear palsy) will be defined using previously
             published research criteria.19-22

        Exclusion Criteria

          -  Features suggestive of other causes of parkinsonism/Parkinson-plus syndromes;

          -  Features suggestive of other causes of dementia, including moderate to severe
             cerebrovascular disease by history, or imaging or history of major head trauma;

          -  History of deep brain stimulation, ablation surgery, or other brain surgery;

          -  Evidence for depression based on the Hospital Anxiety Depression Scale (score > 11).
      

Gender

All

Ages

40 Years - N/A

Accepts Healthy Volunteers

No

Contacts

benzi Kluger, MD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT02132052

Organization ID

11-0952


Responsible Party

Sponsor

Study Sponsor

University of Colorado, Denver


Study Sponsor

benzi Kluger, MD, Principal Investigator, University of Colorado, Denver


Verification Date

June 2021