Brief Title
Cognitive Impairement In Frontotemporal Dementia
Official Title
Cognitive Impairement In Frontotemporal Dementia
Brief Summary
This is an observational study that aims to better understand the genetic causes of
frontotemporal degeneration (FTD), Multiple Systems Atrophy (MSA), and Progressive
Supranuclear Palsy (PSP). It is hoped the information gathered in this study will help lead
to better diagnostics and future treatments.
Detailed Description
Comparative and longitudinal studies reveal clinical differences between subgroups of
patients with frontotemporal dementia (FTD), including Progressive Non-fluent Aphasia (PNFA),
Semantic Dementia (SD), patients with a disorder of social comportment and personality (SOC),
and non-aphasic patients with executive dysfunction (EXEC). MRI studies of cortical atrophy
and fMRI studies show correlated neural defects in FTD subgroups. The investigators will
obtain converging evidence from multiple sources to test hypotheses about the neural basis
for cognitive functions such as semantic memory, grammatical processing, and social
functioning in these FTD subgroups, while improving clinical care for these patients. Recent
studies have linked progressive supra nuclear palsy (PSP) and multiple systems atrophy (MSA)
to FTD. The investigators will obtain comparable neuropsychological and biomarker data in
order to compare these patient groups.
Study Type
Observational
Primary Outcome
Progression
Secondary Outcome
Impaired semantic memory in Semantic Dementia (SD).
Condition
Frontotemporal Degeneration
Intervention
None-Observation Only
Study Arms / Comparison Groups
FTD Cohort
Description: No intervention-observation only
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
997
Start Date
July 1, 2003
Completion Date
July 15, 2020
Primary Completion Date
July 15, 2020
Eligibility Criteria
Inclusion Criteria:
- Individuals who have been diagnosed with FTD, PSP, and MSA
Exclusion Criteria:
- Individuals under 18 years of age
- People with pacemakers or certain metallic implants
- pregnant women
Gender
All
Ages
18 Years - N/A
Contacts
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Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT03452956
Organization ID
298201
Responsible Party
Sponsor
Study Sponsor
University of Pennsylvania
Study Sponsor
, ,
Verification Date
November 2020