Rehabilitation in Patients With Progressive Supranuclear Palsy

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Brief Title

Rehabilitation in Patients With Progressive Supranuclear Palsy

Official Title

Rehabilitation in Patients With Progressive Supranuclear Palsy: Effectiveness of Two Intensive Protocols

Brief Summary

      The investigators evaluate whether an aerobic, intensive, goal based and multidisciplinary
      rehabilitation treatment, previously conceived for Parkinson's disease, is effective for
      patients with progressive supranuclear palsy and whether a driven gait orthosis (Lokomat) can
      provide further benefits.
    



Study Type

Interventional


Primary Outcome

PSPRS

Secondary Outcome

 BBS

Condition

Progressive Supranuclear Palsy

Intervention

MIRT

Study Arms / Comparison Groups

 MIRT group
Description:  This group underwent a 4-weeks MIRT exploiting the use of a treadmill-plus (treadmill associated with visual cues and auditory feedbacks).
Inclusion criteria: a) diagnosis of idiopathic PSP in accordance to the NINDS-SPSP International Criteria (Litvan et al., 1996), b) age between 55 and 85 c) ability to walk unassisted for at least 6 meters, d) stable dopaminergic drugs dosage in the month preceding the admission to the study. Exclusion criteria: a) any others significant neurological or orthopedic disorders, b) osteoarthritis, osteoporosis, cutaneous lesions and/or other pressure wounds, c) body weight exceeding 135 kg (the weight limit for the use of Lokomat®), respiratory and cardiovascular diseases.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

24

Start Date

April 2014

Completion Date

December 2015

Primary Completion Date

December 2015

Eligibility Criteria

        Inclusion Criteria:

        a) diagnosis of PSP in accordance to the NINDS-SPSP International Criteria (Litvan et al.,
        1996), b) age between 55 and 85 c) ability to walk unassisted for at least 6 meters, d)
        stable dopaminergic drugs dosage in the month preceding the admission to the study

        Exclusion Criteria:

        a) any others significant neurological or orthopedic disorders, b) osteoarthritis,
        osteoporosis, cutaneous lesions and/or other pressure wounds, c) body weight exceeding 135
        kg (the weight limit for the use of Lokomat®), respiratory and cardiovascular diseases.
      

Gender

All

Ages

55 Years - 85 Years

Accepts Healthy Volunteers

No

Contacts

Giuseppe Frazzitta, MD, , 

Location Countries

Italy

Location Countries

Italy

Administrative Informations


NCT ID

NCT02109393

Organization ID

PSP-MIRTLoko

Secondary IDs

PSP MIRT-Loko 001

Responsible Party

Sponsor

Study Sponsor

Ospedale Generale Di Zona Moriggia-Pelascini


Study Sponsor

Giuseppe Frazzitta, MD, Principal Investigator, Ospedale generale di Zona "Moriggia-Pelascini", Gravedona ed Uniti 22015 - CO, Italy


Verification Date

November 2016