Brief Title
Risk Factors for Progressive Supranuclear Palsy (PSP)
Official Title
Genetic and Environmental Risk Factors for PSP
Brief Summary
Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian movement
disorder. This study will determine the role of specific genetic, occupational and
environmental components in the development of PSP by evaluating patients with this disorder
and age and gender matched controls.
Detailed Description
This proposal will determine: (1) if there is an association between PSP and specific genes
of interest; (2) if there is an association between PSP and occupational and/or environmental
chemical exposures functionally or structurally similar to known parkinsonian toxicants; and
(3) if hypertension or traumatic brain injury prior to symptom-onset is associated with PSP.
To disentangle the complex etiology of PSP, this case-control multicenter study involves 500
PSP cases, 500 age/gender matched primary controls, and 500 secondary controls for genetic
confirmation. Understanding the etiology of PSP may also help explain the causes of other
related diseases such as Alzheimer's disease. This multidisciplinary team of movement
disorder specialists, epidemiologists, geneticists, biostatisticians, industrial hygienist
and toxicologist is well suited to unravel the etiology of PSP.
Study Type
Observational
Condition
Progressive Supranuclear Palsy
Study Arms / Comparison Groups
Case
Description: PSP Cases
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
942
Start Date
August 2006
Completion Date
June 2013
Primary Completion Date
February 2013
Eligibility Criteria
Inclusion Criteria:
- PSP patients able to visit one of the screening sites for diagnostic confirmation and
able to participate in a one hour telephone interview
Exclusion Criteria:
- No other major neurological disorders
- Unable to communicate by telephone
Gender
All
Ages
40 Years - N/A
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Irene Litvan, M.D., ,
Location Countries
Canada
Location Countries
Canada
Administrative Informations
NCT ID
NCT00431301
Organization ID
1R01AG024040-01A2
Secondary IDs
1R01AG024040-01A2
Responsible Party
Sponsor
Study Sponsor
University of Louisville
Collaborators
National Institute on Aging (NIA)
Study Sponsor
Irene Litvan, M.D., Principal Investigator, University of Louisville
Verification Date
April 2017