Subcutaneous Apomorphine in the Treatment of Progressive Supranuclear Palsy and Cortico Basal Degeneration (APOPARKA)

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Brief Title

Subcutaneous Apomorphine in the Treatment of Progressive Supranuclear Palsy and Cortico Basal Degeneration (APOPARKA)

Official Title

Subcutaneous Apomorphine in the Treatment of Progressive Supranuclear Palsy and Cortico Basal Degeneration (APOPARKA)

Brief Summary

      Treatment of tauopathies such as Progressive Supranuclear Palsy (PSP) and Cortico Basal
      Degeneration (CBD) remains a major challenge. These rare severe neurodegenerative
      extrapyramidal movement disorders share phenotypic overlap and are usually painful. Parkinson
      disease (PD) is a common extrapyramidal movement disorder and continuous subcutaneous
      apomorphine infusion (CSAI) is commonly used in advanced PD patients to alleviate motor and
      non-motor fluctuations. Effects of subcutaneous apomorphine were investigated especially on
      pain and, on quality of life in 7 patients with PSD or CBD.This is an observational "real
      life" surveillance-based study.The Verbal Rating Scale for Pain (VRS) was used to assess
      changes in pain level and the clinical global impression-improvement scale (CGI-I) was used
      to assess changes in patient's illness before and during six months of treatment. Detailed
      report of the symptoms and side effects has been recorded by home nurses throughout the study
      period.

Study Type

Observational

Primary Outcome

Effects of subcutaneous apomorphine on pain

Condition

Progressive Supranuclear Palsy

Intervention

Apomorphine

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Drug

Estimated Enrollment

7

Start Date

December 1, 2018

Completion Date

July 1, 2020

Primary Completion Date

June 1, 2020

Eligibility Criteria

        Inclusion Criteria:

          -  PSP or CBD patients for whom a treatment with subcutaneaous apomorphine is indicated

        Exclusion Criteria:

          -  Pregnant or breastfeeding women

          -  Patient under a legal protection procedure

          -  Patient denying to participated to the study

          -  Lack of affiliation to a social security system

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

, ,

Location Countries

France

Location Countries

France

Administrative Informations

NCT ID

NCT04786158

Organization ID

CE_20200204_5_CHH

Responsible Party

Sponsor

Study Sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Study Sponsor

, ,

Verification Date

March 2021