The Effects of Exercise Training in Children With Hemophilia

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Efficacy and Safety Study of Human-cl rhFVIII in PTPs With Severe Hemophilia A Clinical Study to Investigate the Pharmacokinetics, Efficacy, Safety and Immunogenicity of a Recombinant FVIII in Patients With Severe Hemophilia A Efficacy and Safety Study of SCT800 for On-demand Treatment With in Patients With Hemophilia A Safety and Efficacy Study of a Recombinant and Protein-Free Factor VIII (rAHF-PFM) in Hemophilia A Patients Undergoing Surgery Safety, Efficacy and Pharmacokinetics of GreenGene™ F to Previously Treated Patients With Severe Hemophilia A Phase 3 Efficacy and Safety Study of BAX 855 in Severe Hemophilia A Patients Undergoing Surgical Procedures The Hemophilia Ultrasound Project An Expanded Access Program of Emicizumab in Participants With Hemophilia A With Inhibitors PF-05208756, Moroctocog Alfa (AF-CC), Xyntha For Hemophilia A Safety and Efficacy Extension Study of GreenGene™ F in Previously Treated Patients Diagnosed With Severe Hemophilia A Pharmacokinetic Comparison of Advate rAHF-PFM With Recombinate rAHF in Patients With Severe Hemophilia A A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Emicizumab Given Every 4 Weeks in Participants With Hemophilia A A Gene Transfer Study for Hemophilia A PHYSICAL ACTIVITY AND FVIII CLEARANCE: RELEVANCE FOR PERSONALIZED THERAPY IN SEVERE HAEMOPHILIA A (PHYSEMO) Prophylaxis Versus on Demand Treatment for Children With Hemophilia A Study of PF-05208756, Moroctocog Alfa (AF-CC), Xyntha For Male Chinese Subjects With Hemophilia A Long-Term Safety and Efficacy of SPK-8011 in Males With Hemophilia A An Open Study to Investigate the Safety and Efficacy of Optivate® in Haemophilia A Patients Undergoing Surgery. Observational Study on Safety of Room Temperature Stable NovoSeven® in Patients With Haemophilia A or B ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD) Pharmacokinetics of Single Bolus Dose of NovoSeven® in Paediatric and Adult Patients With Haemophilia A or B in a Non- Bleeding State Investigating Safety and Pharmacokinetics of 2 Different Single Doses of NNC128-0000-2011 in Haemophilia A or B Patients Safety and Mode of Action of a Single Dose and Multiple Doses of Long Acting Activated Recombinant Human Factor VII in Patients With Haemophilia A and B Gene Therapy for Haemophilia A. Health Related Quality of Life of Youth and Young Adults With Hemophilia A Trial to Evaluate the Effect of Secondary Prophylaxis With rFVIII Therapy in Severe Hemophilia A Adult and/or Adolescent Subjects Compared to That of Episodic Treatment Web-based Application for the Population Pharmacokinetic Service – Phase 1 Assessing Physician and Hemophilia A Patient Reasons and Expectations for Switching Treatment to Kovaltry & Jivi: A Nested Study Within an Existing Registry Study Comparing Blood Levels of ReFacto and Advante in Hemophilia A Safety and Pharmacokinetics of Subcutaneous Injection of OCTA101 in Adult Patients With Severe Hemophilia A Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Safety/Efficacy Study to Assess Whether FVIII/VWF Concentrate Can Induce Immune Tolerance in Haemophilia A Patients Multicentre, Non-controlled, Prospective, Post-Marketing Safety Study Following Long-Term Prophylactic OptivateTreatment in Subjects With Severe Haemophilia A Validation Study of a cOmputer Pharmacokinetic Tool to assIst in the Follow up Care of haeMophilia A Patients Joint Status in Subjects With Severe Hemophilia A in Relation to Different Treatment Regimens Safety Study of Alphanate in Previously Treated Patients With Severe Hemophilia A Treatment of Hemophilia A Patients With FVIII Inhibitors Comparison of Prophylaxis and On-demand Treatment in Children With Moderate to Severe Hemophilia A An Open Label Study to Determine the Safety and Efficacy of Replacement Factor VIII Protein (Known as rFVIIIFc) in Untreated Males With Severe Hemophilia A Assessment of the Risk of Inhibitor Formation in Previously Treated Patients With Severe Hemophilia A Efficacy and Safety of ADVATE Standard Prophylaxis to Hemophilia A Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec, With Prophylactic Steroids in Hemophilia A National Study of a Pharmacokinetic-Focused Educational Package for Patients With Severe Haemophilia A Gene Therapy Trial for Platelet Derived Factor VIII Production in Hemophilia A Drug Use Investigation of Kovaltry in Hemophilia A Patients Safety, Immunogenicity and Hemostatic Efficacy of PEGylated Recombinant FVIII (BAX 855) in Previously Untreated Patients (PUPs) < 6 Years of Age With Severe Hemophilia A 2-cohort Study of Adult Patients With Severe Hemophilia A in Greece Study of Emicizumab Prophylaxis in Participants With Hemophilia A With or Without Inhibitors Undergoing Minor Surgical Procedures Efficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A Participants Individually Tailored Prophylaxis in Patients With Severe Hemophilia A Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients Retrospective Chart Review to Evaluate Safety and Tolerability of ADVATE Among Previously Untreated Patients in China With Moderate to Severe Hemophilia A Comparison of 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A Trial Investigating Safety and Efficacy of Treatment With BAY94-9027 in Severe Hemophilia A Joint Health Study Study Evaluating Safety And Efficacy Of Moroctocog Alfa (AF-CC) In Previously Treated Hemophilia A Patients A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitors UK – EHL Outcomes Registry Study to Establish Bioequivalence of ReFacto AF (BDDrFVIII) With Advate (FLrFVIII) in Hemophilia A Evaluation of Long-term Safety of ADYNOVI/ADYNOVATE (Antihaemophilic Factor [Recombinant] PEGylated, Rurioctocog Alfa Pegol) in Patients With Haemophilia A – An ADYNOVI/ADYNOVATE Post-Authorisation Safety Study (PASS) Platelet Function in Patients With Hemophilia A Study to Learn More About the Physical Activity Level of Patients Suffering From Hemophilia A Treated With Damoctocog Alfa Pegol (LIFE ACTIVE Study) Pharmacokinetic Characterization of the Hemophilia A Population in Spain Using myPKFiT® Impact of Conservative 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Pain, Depression and Anxiety, in People With Haemophilia A and B The Dynamic Interplay Between Bleeding Phenotype and Baseline Factor Level in Moderate and Mild Hemophilia A and B RIXUBIS Drug Use-Result Survey (Japan) A Study of Fitusiran (ALN-AT3SC) in Severe Hemophilia A and B Patients With Inhibitors Evaluating Effectiveness and Long Term Safety of Damoctocog Alfa Pegol in Patients, Who Have Been Diagnosed With Hemophilia A Extended Half Life Factor (EHF) Products For Heavy Menstrual Bleeding in Hemophilia Carriers Study Evaluating ReFacto® in Hemophilia A Undergoing Major Surgery A Non-interventional Retrospective Study of the Current Treatment Practice in European Haemophilia Care BAX 326 Pediatric Study Recombinant Factor VIIa BI (rFVIIa BI) Treatment of Acute Bleeding Episodes Per an On-demand Regimen A Phase 1 Study of an Investigational Drug, ALN-AT3SC, in Healthy Volunteers and Hemophilia A or B Patients A Study of a Long-Acting r-Factor 7a (Factor VIIa) in Adult Men With Hemophilia A or B Females With Severe or Moderate Hemophilia A or B: an International Multi-center Study Females With Severe or Moderate Hemophilia A or B: A Multi-Center Study Socialization of Adult Men With Congenital Hemophilia A or B Study of Prophylaxis, ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated With ADVATE or RIXUBIS An Observational Study to Evaluate Physical Activity, Bleeding Incidence and Health Related Quality of Life, in Participants With Haemophilia A Without Inhibitors Receiving Standard of Care Treatment Inhibitor Development in Patients With Hemophilia A Undergoing Surgery Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Patients With Severe Hemophilia A or B Post-marketing Surveillance (Use Result Surveillance) With Refixia® Study Evaluating of Recombinant Human Factor IX (BeneFIX) and a New Formulation of BeneFIX (rFIX-R) in Moderate to Severe Hemophilia B A Study of Fitusiran (ALN-AT3SC) in Severe Hemophilia A and B Patients Without Inhibitors Phase I/II Study of Monoclonal Factor IX Concentrate for Factor IX Deficiency The Effectiveness of Recombinant Fusion Protein Linking Coagulation Factor IX With Recombinant Albumin (rIX-FP) in Severe Hemophilia B Patients Switching From Previous Factor IX Treatment The Safety and Tolerability of SerpinPC in Healthy Men and in Men With Severe Blood Disorders (Haemophilia A and B) IMMUNINE Pre-Treatment Study Efficacy and Safety of NNC-0156-0000-0009 During Surgical Procedures in Subjects With Haemophilia B Study of Ataluren (PTC124®) in Hemophilia A and B Safety of 40K Pegylated Recombinant Factor IX in Non-Bleeding Patients With Haemophilia B Fc factOrs and Real-World hemophiliA Patient-ReporteD Outcomes Bridging Hemophilia B Experiences, Results and Opportunities Into Solutions (B-HERO-S) Study Evaluating Approach to Treatment of Haemophilia A and B in Spain Global Epidemiologic Study of Preexisting Immunity to AAV in Adults With Severe Hemophilia Safety and Efficacy of Nonacog Beta Pegol (N9-GP) in Previously Untreated Patients With Haemophilia B Ascending Dose Study of Genome Editing by Zinc Finger Nuclease Therapeutic SB-FIX in Subjects With Severe Hemophilia B Safety and Efficacy of NNC-0156-0000-0009 After Long-Term Exposure in Patients With Haemophilia B: An Extension to Trials NN7999-3747 and NN7999-3773 Study Evaluating rFIX; BeneFIX® in Hemophilia B A Trial Comparing Nonacog Beta Pegol (N9-GP) and ALPROLIX® in Patients With Haemophilia B Tissue Factor Pathway Inhibitor (TFPI) and Haemorrhagic Manifestations in Haemophilia A and B Patients Safety and Pharmacokinetic Study of a Recombinant Coagulation Factor IX Albumin Fusion Protein in Subjects With Hemophilia B Long-term Safety and Efficacy Study of SPK-9001 in Individuals With Hemophilia B BAX 326 (rFIX) Continuation Study Nonacog Alfa Prophylaxis And Treatment Of Bleeding Episodes In Previously Treated Patients With Hemophelia B A Factor IX Gene Therapy Study (FIX-GT) Mutation p.Ile112Thr : Discrepancy Between Factor IX Level and Bleeding Phenotype LTFU for Gene Transfer Subjects With Hemophilia B A Phase 1/2 Study of SHP648, an Adeno-Associated Viral Vector for Gene Transfer in Hemophilia B Subjects Adverse Event Data Collection From External Registries on Nonacog Beta Pegol Safety and Efficacy of NNC-0156-0000-0009 in Haemophilia B Patients Lentiviral FIX Gene Therapy An Open Study to Investigate the Safety and Efficacy of Replenine®-VF in Severe Haemophilia B Patients Study to Describe the Allergic Reactions to Factor IX in Patients With Hemophilia B A Study to Evaluate the Real-world Usage and Effectiveness of Elocta and Alprolix in Patients With Haemophilia A or B A Long-Term Follow-Up Study of Haemophilia B Patients Who Have Undergone Gene Therapy A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B Long-Term Safety, Tolerability, and Efficacy of DTX101 (AAVrh10FIX) in Adults With Moderate/Severe to Severe Hemophilia B Post-Marketing Surveillance (Usage Results Study) of RIXUBIS in Adult and Pediatric Patients With Haemophilia B in South Korea Evaluation of a Recombinant Factor IX Product, APVO101, in Previously-Treated Pediatric Patients With Hemophilia B Understanding Hemophilia A and B Drug Dosage Administration Patterns Study of Recombinant Factor IX Product, IB1001, in Previously Treated Subjects With Hemophilia B Phase I/IIa Study of FIXFc in Hemophilia B Patients Safety, Efficacy and Pharmacokinetics of NNC-0156-0000-0009 in Previously Treated Children With Haemophilia B. A Study to Investigate the Safety and Efficacy of Replenine®-VF in Haemophilia B Patients Undergoing Major Surgery. HOPE-B: Trial of AMT-061 in Severe or Moderately Severe Hemophilia B Patients Long-Term Safety and Efficacy of rFIXFc in the Prevention and Treatment of Bleeding Episodes in Previously Treated Participants With Hemophilia B Study Evaluating Allergic Reactions To Benefix In Hemophilia B Patients A Safety and Efficacy Extension Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Patients With Hemophilia B Study to Determine the Safety and Efficacy of rFIXFc in Untreated Males With Severe Hemophilia B Safety and Dose Finding Study of DTX101 (AAVrh10FIX) in Adults With Moderate/Severe to Severe Hemophilia B Open-Label Single Ascending Dose of Adeno-associated Virus Serotype 8 Factor IX Gene Therapy in Adults With Hemophilia B Prospective Registry of European Hemophilia B Patients Receiving BeneFIX® for Usual Use A Safety, Efficacy and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Children With Hemophilia B Study of Recombinant Factor IX Product, IB1001, in Subjects With Hemophilia B A Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B in France An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B Study Evaluating BeneFIX in Patients With Haemophilia B, Previously Treated With Plasma Derived Factor IX A Gene Therapy Study for Hemophilia B A Safety and Efficacy Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Patients With Hemophilia B A Study Following Males With Haemophilia B on Prophylaxis With Refixia/REBINYN A Safety and Efficacy Study of a Recombinant Factor IX in Patients With Severe Hemophilia B Gene Therapy for Chinese Hemophilia B BeneFIX Drug Use Results Survey [All-Case Surveillance] Safety of a New Type of Treatment Called Gene Transfer for the Treatment of Severe Hemophilia B Treatment Patterns And Outcomes In Patients Treated With Benefix Or Refacto/Refacto AF – A Swedish Cohort Study Hemophilia B Gene Therapy With AAV8 Vector Dose-Escalation Study Of A Self Complementary Adeno-Associated Viral Vector For Gene Transfer in Hemophilia B Study of Recombinant Factor IX Fc Fusion Protein (rFIXFc) in Participants With Hemophilia B Post Marketing Observational Study of Reformulated BeneFIX Study of Recombinant Factor IX Product, IB1001, in Previously Treated Pediatric Subjects With Hemophilia B Study of Next-Generation Recombinant Factor IX Variant in Adult Subjects With Hemophilia B An Open-Label, Single Dose Pharmacokinetic Study of Benefix (Recombinant Factor IX) in Male Chinese Subjects With Hemophilia B A Study to Investigate the Safety and Efficacy of Replenine®-VF in Haemophilia B Patients Under the Age of 6 Years Study of Recombinant Coagulation Factor IX Fc Fusion Protein, BIIB029, in Previously Treated Pediatric Participants With Hemophilia B An Open-study to Investigate the Safety and Efficacy of Replenine®-VF in Haemophilia B Subjects Undergoing Surgery Post Marketing Surveillance To Observe Safety and Efficacy Of BeneFIX In Patients With Hemophilia B BAX 326 Surgery Study in Hemophilia B Patients Registry For Patients Treated With BeneFix In Usual Care Setting In Germany Six Month lead-in Study to Evaluate Prospective Efficacy and Safety Data of Current FIX Prophylaxis Replacement Therapy in Adult Hemophilia B Subjects (FIX:C≤2%) or Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Subjects (FVIII:C≤1%) Trial of AAV5-hFIX in Severe or Moderately Severe Hemophilia B Study Comparing On-Demand Treatment With Two Prophylaxis Regimens Of BeneFIX In Patients With Severe Hemophilia B Study Evaluating On-Demand Treatment With BeneFIX In Chinese Subjects Study Evaluating rFIX; BeneFIX in Severe Hemophilia B Study To Compare On-Demand Treatment To A Prophylaxis Regimen Of BeneFIX In Subjects With Moderately Severe to Severe Hemophilia B Dose-escalation Study to Investigate the Safety, PK, and PD of ISU304/CB2679d in Hemophilia B Patients Post Marketing Study in Haemophilia B Patients Using Nonafact® (Human Coagulation Factor IX) A Study to Compare the Pharmacokinetics and Safety of Replenine®-VF, Replenine® or Other Factor IX in Haemophilia B Efficacy and Safety of AlphaNine Versus BeneFIX in Patients With Severe Hereditary Haemophilia B Study Evaluating BENEFIX in Previously Treated Patients With Hemophilia B Safety and Efficacy of Benefix in Patients With Hemophilia B in Usual Care Settings in China

Brief Title

The Effects of Exercise Training in Children With Hemophilia

Official Title

The Effects of Exercise Training on Physical Activity Level, Daily Living Activities and Participation in Children With Hemophilia

Brief Summary

      This study aims to investigate the effects of an individually planned exercise program,
      counseling and family education on the followings in patients with hemophilia (PWH);

        1. To examine the joint range of motion, muscle strength and functional status.

        2. To evaluate the level of physical activity and daily living activities

        3. To aim to determine the amount of change after participation.
    

Detailed Description

      Hemophilia is defined as bleeding in the musculoskeletal system and soft tissues as a result
      of the lack of clotting factors in the blood. Recurrent attacks of hemarthrosis cause pain,
      also because of the pain patients tend to use joints less than usual. The decrease in joint
      movement makes it harder to return to active movement again. There is a limited literature on
      the effects of exercise on children with hemophilia.

      Hemophilia is a hereditary bleeding disorder that develops as a result of factor VIII or IX
      deficiency; it is a rarely seen disease that discloses itself by hemarthrosis and
      intramuscular bleeding. Factor VIII deficiency is called Hemophilia A and Factor IX
      deficiency is called Hemophilia B. This disease is inherited by the X chromosome and passes
      on to male children through female carriers. Although Hemophilia A is observed rarely, one in
      about 5,000-10,000 male births, its frequency is still 5-6 times higher than Hemophilia B.
      Around 70% of hemophilia A patients have more severe disease, however, this rate is
      approximately 50% in hemophilia B.

      Hemophilia patients experience bleeding in the musculoskeletal system and soft tissues as a
      result of the lack of clotting factors in the blood. Recurrent attacks of hemarthrosis cause
      pain, also because of the pain patients tend to use joints less than usual. Decrease in joint
      movement makes it harder to return to active movement again in the majority of the cases,
      bleeding occurs into the joint (mostly the knee, elbow and ankle) and only a small part of
      the bleedings occurs into the muscle (especially the iliopsoas, calf and forearm muscles).

      In order to be able to participate according to the international classification of functions
      of health (ICF), it is prioritized that the activities are functional.

      Targeted treatment is a functional treatment application that conforms to ICF's "activities
      and participation among children. An activity is carrying out of a task or movement by an
      individual and the difficulties faced while carrying out the tasks or movements is called
      limitations. Participation means the individual's being in life. In life conditions, problems
      confronted are participation restrictions. Activity limitations can often lead to
      participation restrictions.

      Fear of bleeding in pediatric patients, particularly from the period of childbirth leads
      families to form an immobile lifestyle for their children compared to healthy individuals.

      The recurrent bleeding often occurs in the lower extremity joints, it causes pain and
      swelling, therefore patients need to keep the joint immobile which is particularly the reason
      why patients spend these periods mostly resting. So then, again, patients forfeit activity
      for fear of recurrent bleeding. The decrease in activity leads to a loss of strength and
      balance. Also, sports that could lead to bleeding or trauma are not suitable for hemophilia
      patients. The benefits and risks of sports activities for hemophilic individuals should be
      well known and the patient should be oriented toward suitable sports. For this reason the
      rehabilitation program should be arranged as a personalized and systematic program according
      to local and general joint and muscle conditions.

      Hematologic therapy alone is not sufficient for the treatment of musculoskeletal bleeding.
      The sedentary lifestyle that develops with hemophilic arthropathy often leads to immobility
      problems such as decreased muscle strength, weak balance and coordination, increased risk of
      obesity. These problems lead to instability and changes in joint loads, thereby instances of
      new bleeding and increased joint damages. In a similar way, after hemarthrosis, in acute
      situations, if the necessary period of resting is not accompanied by an appropriate
      physiotherapy, it causes a vicious cycle of immobility, new bleeding and eventually
      hemophilic arthropathy and loss of function.

      The key to the successful management of hemophilic arthropathy is to begin the treatment
      early. The first step of treatment for hemophilic arthropathy is physiotherapy with factor
      replacement to prevent bleeding attacks and joint damage before hemarthrosis progresses to
      chronic synovitis and joint erosion.

      Physical activity means body movement by using energy and exercise means planned physical
      activities that are personally structured. Regular exercise can prevent the progression of
      hemophilic arthropathy or it may reduce the risk. Therapeutic exercises are the main elements
      of rehabilitation for Patients with hemophilic arthropathy and muscle bleeding.

      The main objective of therapy should be the following: restoration or preservation of range
      of motion, strengthening of muscles, prevention or treatment of joint contracture, pain
      management, increasing exercise tolerance, improvement of balance, coordination, and
      proprioception. To prevent patients from giving up on exercising earlier than required, İt is
      important to assist patients, encourage them during exercises, support them and when
      necessary give them advice and explain the exercises in a way that patients can easily and
      clearly understand. There is a fine line between beneficial and harmful activities, this fine
      line leads many patients with bleeding disorder to avoid exercise for fear of causing
      bleeding. Paradoxically, when people with bleeding disorders avoid exercising this causes
      decreased function, range of motion, and quality of life because of muscle weakness.

      In Turkey, the cost of joint health complications in patients with hemophilia and other
      inherited bleeding disorders is significantly high however most significant point is that
      these costs can be avoided. Physical activity which is a non-pharmacologic treatment method,
      plays an important role in reducing the risks, alleviating the symptoms and improving the
      results in hemophilia. For this reason, it is very important to develop strategies to
      increase the level of physical activity.

      In the relevant literature there are very few studies on the effects of exercise in pediatric
      patients with hemophilia. With this study, we plan to show, in an objective manner, that the
      personally planned exercise program leads to change in the level of physical activity,
      activities of daily life and participation.

      The Methods of the Study

      Before the study the patients and their families will be informed about the evaluations,
      treatments that will be made. They will be also informed about outcomes and evaluations after
      the treatment, and the risks that they may face during the the treatments. They will also be
      asked to sign the "Informed Consent Form" for their voluntary participation in the study.

      An "Assessment Form" will be prepared in order to keep the record of demographic and disease
      information of all the cases included in the study. Hemophilia types, patients biographic
      information, family history, the time when the disease was diagnosed, treatments taken,
      medications used, body mass index, range of motion and muscle strength will be recorded in
      this assessment form.

      Randomly patients will be divided into two groups as physical activity counseling and
      individually planned exercise group and only physical activity counseling group. We plan that
      the exercise will be done for 50 minutes a day, twice in a week and will last for 8 weeks.

      Before and after the 8-week intervention program of all patients physical activity levels
      with International Physical Activity Questionnaire (IPAQ), activity performance exercise with
      Children's Functional Independence Scale (Wee-FIM) and Canadian Occupational Performance
      Measurement (COPM), joint health with hemophilia joint health scoring (HESS), exercise
      capacity with 6-minute walking test (6MWT) and sit-and-stand test, hand function speed and
      dexterity with Jebsen-Taylor Hand Function Test (JTHFT) and quality of life with Pediatric's
      Quality of life Scale (PedsQL) will be evaluated.

      Assessment methods, exercise and counseling practices will be carried out in the Turkey
      Hemophilia Society of Physiotherapy Unit.Only the participants in the hematologists follow-up
      will continue their routine doctor checks and recommendations.

      All analyzes will be performed using Statistical Package for Social Sciences (SPSS) for
      Windows 22. The compliance of the data to normal distribution will be evaluated by drawing
      the Kolmogorov-Smirnov test and histogram. Parametric tests will be used for data suitable
      for normal distribution. Data that are not suitable for normal distribution will be analyzed
      with non-parametric tests. Variables will be defined by their mean and standard deviation
      values. Analyzes and correlations between groups will be examined separately with appropriate
      tests. A value of p<0.05 will be considered statistically significant.
    


Study Type

Interventional


Primary Outcome

Hemophilia Joint Health Scoring (HJHS)

Secondary Outcome

 Long version of International Physical Activity Questionnaire (IPAQ)

Condition

Hemophilia

Intervention

Experimental group 1

Study Arms / Comparison Groups

 Experimental group 1
Description:  physical activity counseling group + exercise group

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Behavioral

Estimated Enrollment

30

Start Date

February 20, 2020

Completion Date

November 20, 2021

Primary Completion Date

September 20, 2021

Eligibility Criteria

        Inclusion Criteria:

          -  Being in the 7-18 age range

          -  Being diagnosed with hemophilia A or B

          -  Having an ongoing prophylactic treatment

          -  Having a heavy or middle Factor level

          -  Volunteering to exercise at 2 days a week in the intervention group within the scope
             of the research

          -  Being able to communicate in Turkish written and verbal

        Exclusion Criteria:

          -  Being in period of active bleeding

          -  Having Body mass index over 30 kg / m²

          -  Having an additional neurological diagnosis that will influence work and cooperation
      

Gender

Male

Ages

8 Years - 18 Years

Accepts Healthy Volunteers

No

Contacts

Ela Tarakcı, prof dr, , 

Location Countries

Turkey

Location Countries

Turkey

Administrative Informations


NCT ID

NCT04703062

Organization ID

13022260-300-63450


Responsible Party

Principal Investigator

Study Sponsor

Istanbul University-Cerrahpasa


Study Sponsor

Ela Tarakcı, prof dr, Study Chair, Istanbul University- Cerrahpasa Physiotherapy and Rehabilitation Department


Verification Date

January 2021