Brief Title
Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients
Official Title
A Phase 3 Open-Label, Single-Arm Study To Evaluate The Efficacy and Safety of BMN 270, an Adeno-Associated Virus Vector-Mediated Gene Transfer of Human Factor VIII in Hemophilia A Patients With Residual FVIII Levels ≤ 1 IU/dL Receiving Prophylactic FVIII Infusions
Brief Summary
This clinical trial is being conducted to learn more about a potential treatment
(valoctocogene roxaparvovec) for people with severe hemophilia A. This research study will
test and confirm the safety and effectiveness of the 6E13 vg/kg dose of the study drug
(valoctocogene roxaparvovec) that contains the correct gene to make Factor VIII so that the
body can make its own Factor VIII that functions properly. Only one dose of valoctocogene
roxaparvovec is being given in this study, and this dose has been previously studied in
another clinical trial in patients with hemophilia A. This is a phase 3 study which is meant
to show that the study drug is safe and works to help treat hemophilia A. The study will see
if liver cells are able to make Factor VIII that functions properly after receiving this
study drug. The study will also examine the effects that the study drug has on how much
Factor VIII concentrates patients have to inject into their veins and on their bleeding
episodes after the study drug has been administered. Finally, the study will see if and how
the body responds to the study drug - for example, whether liver cells become inflamed or
whether the body makes antibodies (something the immune system makes to protect itself
against things like bacteria and viruses) against the vector or the new Factor VIII gene.
Study Phase
Phase 3
Study Type
Interventional
Primary Outcome
Change of the median FVIII activity
Secondary Outcome
Change in the annualized utilization (IU/kg) of exogenous FVIII replacement therapy
Condition
Hemophilia A
Intervention
valoctocogene roxaparvovec
Study Arms / Comparison Groups
valoctocogene roxaparvovec Open Label
Description: Single administration of valoctocogene roxaparvovec at a dose of 6E13 vg/kg
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Biological
Estimated Enrollment
134
Start Date
December 19, 2017
Completion Date
September 2023
Primary Completion Date
December 2022
Eligibility Criteria
Inclusion Criteria:
- Males ≥ 18 years of age with hemophilia A and residual FVIII levels ≤ 1 IU/dL as
evidenced by medical history, at the time of signing the informed consent.
- Must have been on prophylactic FVIII replacement therapy for at least 12 months prior
to study entry. High-quality, well-documented historical data concerning bleeding
episodes and FVIII usage over the previous 12 months must be available.
- Treated/exposed to FVIII concentrates or cryoprecipitate for a minimum of 150 exposure
days (EDs).
- No previous documented history of a detectable FVIII inhibitor, and results from a
Bethesda assay or Bethesda assay with Nijmegen modification of less than 0.6 Bethesda
Units (BU) (or less than 1.0 BU for laboratories with a historical lower sensitivity
cutoff for inhibitor detection of 1.0 BU) on 2 consecutive occasions at least one week
apart within the past 12 months (at least one of which should be tested at the central
laboratory).
Exclusion Criteria:
- Detectable pre-existing antibodies to the AAV5 capsid.
- Any evidence of active infection or any immunosuppressive disorder, including HIV
infection.
- Significant liver dysfunction with any of the following abnormal laboratory results:
- ALT (alanine aminotransferase) > 1.25x ULN;
- AST (aspartate aminotransferase) > 1.25x ULN;
- GGT (gamma-glutamyltransferase) > 1.25x ULN;
- Total bilirubin > 1.25x ULN;
- Alkaline phosphatase > 1.25x ULN
- INR (international normalized ratio) ≥ 1.4.
Subjects whose liver laboratory assessments fall outside of these ranges may undergo repeat
testing of the entire liver test panel within the same Screening window and, if eligibility
criteria are met on retest, may be enrolled after confirmation by the Medical Monitor.
- Prior liver biopsy showing significant fibrosis of 3 or 4 as rated on a scale of 0-4
on the Batts-Ludwig (Batts 1995) or METAVIR (Bedossa 1996) scoring systems, or an
equivalent grade of fibrosis if an alternative scale is used.
- Evidence of any bleeding disorder not related to hemophilia A.
- Platelet count of < 100 x 10^9/L.
- Creatinine ≥ 1.5 mg/dL.
- Liver cirrhosis of any etiology as assessed by liver ultrasound.
- Chronic or active hepatitis B as evidenced by positive serology testing (hepatitis B
surface antigen [HBsAg], hepatitis B surface antibody [HBsAb], and hepatitis B core
antibody [HBcAb]) and confirmatory HBV DNA testing. Refer to the Centers for Disease
Control (CDC) table for the interpretation of serological test results.
- Active Hepatitis C as evidenced by detectable HCV RNA or currently on antiviral
therapy.
- Active malignancy, except non-melanoma skin cancer.
- History of hepatic malignancy.
- History of arterial or venous thromboembolic events (eg, deep vein thrombosis,
nonhemorrhagic stroke, pulmonary embolism, myocardial infarction, arterial embolus),
with the exception of catheter-associated thrombosis for which anti-thrombotic
treatment is not currently ongoing.
- Known inherited or acquired thrombophilia, including conditions associated with
increased thromboembolic risk, such as atrial fibrillation.
Gender
Male
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Medical Monitor, MD, ,
Location Countries
Australia
Location Countries
Australia
Administrative Informations
NCT ID
NCT03370913
Organization ID
BMN 270-301
Secondary IDs
2017-003215-19
Responsible Party
Sponsor
Study Sponsor
BioMarin Pharmaceutical
Study Sponsor
Medical Monitor, MD, Study Director, BioMarin Pharmaceutical
Verification Date
July 2020