Brief Title
Study to Evaluate Safety and Tolerability of a Single Dose of PF-06741086 in Chinese Adult Participants With Severe Hemophilia
Official Title
A PHASE 1, SINGLE-ARM, OPEN-LABEL, NON-RANDOMIZED, NON-CONTROLLED MULTICENTER STUDY TO EVALUATE THE PHARMACOKINETICS, PHARMACODYNAMICS, SAFETY, AND TOLERABILITY OF A SINGLE SUBCUTANEOUS DOSE OF PF-06741086 IN CHINESE ADULT PARTICIPANTS WITH SEVERE HEMOPHILIA
Brief Summary
This Phase 1 study will be a single-arm, open-label, non-randomized, non-controlled investigation of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06741086 in Chinese adult participants with severe hemophilia.
Study Phase
Phase 1
Study Type
Interventional
Primary Outcome
Percentage of participants by severity and causal relationship of treatment emergent adverse events (TEAEs)
Secondary Outcome
Plasma PF 06741086 concentrations
Condition
Severe Hemophilia
Intervention
PF-06741086
Study Arms / Comparison Groups
single arm
Description: PF-06741086 300mg subcutaneous(SC)
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Biological
Estimated Enrollment
6
Start Date
April 16, 2021
Completion Date
August 10, 2021
Primary Completion Date
August 10, 2021
Eligibility Criteria
Inclusion Criteria: - Participant must be male and 18 to <75 years of age with a minimum body weight of 30 kg at screening. - Participants with a diagnosis of severe hemophilia A or B (FVIII or FIX activity <1%, respectively) - Participants without inhibitor must also meet the following criteria: - No detectable or documented history of inhibitors - Participants with on-demand treatment regimen with ≥6 acute bleeding episodes (spontaneous or traumatic) that required coagulation factor infusion during the 4 months period prior to enrollment and willing to continue to receive on demand treatment during the study. - Participants with Inhibitor must also meet the following criteria: - Documentation of current high titer inhibitor (≥5 BU/mL) or current low titer inhibitor (<5 BU/mL) refractory to FVIII or FIX replacement and with FVIII or FIX recovery <60% of expected within previous 4 months prior to screening. - Participants with on-demand treatment regimen with ≥6 bleeding episodes (spontaneous and/or traumatic) necessitating treatment with bypass factor for at least 4 months prior to screening and willing to continue to receive on-demand treatment during the study. Exclusion Criteria: - Previous or current treatment for and/or history of coronary artery diseases, venous or arterial thrombosis or ischemic disease - Known planned surgical procedure during the planned study period. - Known hemostatic defect other than hemophilia A or B. - Abnormal renal or hepatic function - Current unstable liver or biliary disease - Abnormal hematologic parameters - Abnormal coagulation activity - Other acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator. - Corrected QT interval (QTc) >450 msec for male participants or QTc >480 msec in participants with bundle branch block. - Individuals with hypersensitivity or an allergic reaction to hamster protein or other components of the study intervention. - A positive urine drug screen - Current routine prophylaxis with bypassing agent or non coagulation factor-replacement therapy (eg, emicizumab) - Regular, concomitant therapy with immunomodulatory drugs - Ongoing or planned use of immune tolerance induction or prophylaxis with FVIII or FIX replacement during the study. - Participation in other studies involving investigational drug(s) within 30 days (or as determined by local requirements) or 5 half-lives prior to study entry and/or during study participation. - CD4 cell count ≤200/uL if human immunodeficiency virus (HIV)-positive - Baseline ECG that demonstrates clinically relevant abnormalities that may affect participant safety or interpretation of study results. - Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or participants who are Pfizer employees, including their family members, directly involved in the conduct of the study
Gender
Male
Ages
18 Years - 74 Years
Accepts Healthy Volunteers
No
Contacts
Pfizer CT.gov Call Center, ,
Location Countries
China
Location Countries
China
Administrative Informations
NCT ID
NCT04878731
Organization ID
B7841010
Responsible Party
Sponsor
Study Sponsor
Pfizer
Study Sponsor
Pfizer CT.gov Call Center, Study Director, Pfizer
Verification Date
September 2021