Brief Title
Posture Analysis for Adolescent Patients With Haemophilia
Official Title
Evaluation of Posture and Mechanical Properties of Muscles in Patients With Haemophilia.
Brief Summary
Hemophilia A and B are inherited disorders characterized by deficient or missing coagulation factors VIII or IX, respectively, of which the main long-term clinical manifestation is joint damage. Patients with haemophilia (PwH) are susceptible to clinical joint bleeding that may cause irreversible joint damage. Some degree of damage may already occur after the first haemarthrosis or even in children who never experienced clinically evident joint bleeds. Joints are mechanical systems with a structure strictly related to functioning. Therefore, any alteration in structure may have an impact on function (starting from the primary level of posture and anti-gravity muscles), which might in turn stress the joints and increase the risk of bleeding.The primary aim of this study is to investigate the changes in posture and the mechanical properties of anti-gravity muscles of adolescent PwH. The secondary aim is to determine the effect of joint dysfunction on posture in adolescent PwH.
Study Type
Interventional
Primary Outcome
Photogrammetry
Secondary Outcome
Haemophilia Joint Health Score
Condition
Hemophilia
Intervention
Posture Analysis
Study Arms / Comparison Groups
Haemophilic boys
Description: Adolescent boys with haemophilia
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Diagnostic Test
Estimated Enrollment
44
Start Date
September 1, 2021
Completion Date
February 15, 2022
Primary Completion Date
January 15, 2022
Eligibility Criteria
Inclusion Criteria: - Adolescent boys with haemophilia A or haemophilia B (for experimental group) and healthy adolescent boys (for control group). Exclusion Criteria: - To be with another congenital coagulopathy such as von Willebrand syndrome. - To be unable to stand without support due to hemophilic arthropathy. - To be having another musculoskeletal problem. - To be developing inhibitors against factor VIII-IX. - To be having plasma level of factor VIII-IX above 6%
Gender
Male
Ages
12 Years - 20 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Nevin A Guzel, Prof. Dr., ,
Location Countries
Turkey
Location Countries
Turkey
Administrative Informations
NCT ID
NCT05173129
Organization ID
109/61
Responsible Party
Principal Investigator
Study Sponsor
Cukurova University
Study Sponsor
Nevin A Guzel, Prof. Dr., Study Director, Gazi University
Verification Date
December 2021