Pegasys® Plus Ribavirin in Hemophilic Patients With Hepatitis C Virus Infection
A Study on PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin) in Iranian Hemophilic Patients With Chronic Hepatitis C Infection
Hemophilic patients are a known high risk groups for acquiring the hepatitis C. The surveillance data from Ministry Of Health in IR.Iran had shown that 60% of them are infected with HCV infection. We are trying the PEGASYS plus Ribavirin in Hemophilic patients with HCV.
The investigators enroll 400 patients into the study. The patients receive PEGASYS (Peginterferon alpha-2a(40 KD)) 180 microgram per week plus COPEGUS (Ribavirin) 800 microgram for Genotype 2 and 3 and 1000 milligram for weight less than 75 kg and 1200 milligram for more than 75 kg. The duration of protocol is depends on genotypes of virus. In genotype 1 and 4, for 48 week and in genotypes 2 and 3 , for 24 weeks. The patients are visited every 4 weeks with biochemistry lab tests. The patients are checked with quantitative HCV RNA on the third months after initiation of the treatment to assess early virologic response and at the end of the study for complete response rate and on the six month after treatment completion for sustained response rate. The patients with undetectable HCV RNA are considered as responders. We have omitted the liver biopsy in the patients.
Early Virologic Response
Tolerability of drugs for whole therapy period
PEGASYS® (Peginterferon Alfa-2a (40KD)) Plus COPEGUS® (Ribavirin)
Study Arms / Comparison Groups
Description: Genotype 2 or 3 in Hemophilic Patients with HCV
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Primary Completion Date
Inclusion Criteria: - HCV RNA positive - Age older than 12 years Exclusion Criteria: - Ongoing pregnancy or breast feeding - Hx of HCC - Hx of alcoholic liver disease - Hx of bleeding from esophageal varices - Hx of hemochromatosis - Hx of autoimmune hepatitis - Hx of Suicidal attempt - Hx of cerebrovascular dis - Hx of severe retinopathy - Hx of severe psoriasis - Hx of scleroderma - Hx of metabolic liver disease - Hx of SLE
12 Years - N/A
Accepts Healthy Volunteers
Professor Seyed-Moayed Alavian, Professor, ,
Iran, Islamic Republic of
Iran, Islamic Republic of
Baqiyatallah Medical Sciences University
Baqiyatallah Research Center for Gastroenterology and Liver Diseases
Professor Seyed-Moayed Alavian, Professor, Study Chair, Baqiyatallah Research Center for Gastroenterology and Liver Diseases