Brief Title
Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet Function
Official Title
Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet Function
Brief Summary
The is study will examine whether variation in clinical bleeding frequency and severity among boys with severe Hemophilia A (Factor VIII deficiency) is associated with variations in laboratory measurements of platelet activity.
Study Type
Observational
Primary Outcome
Procoagulant platelet-derived microparticle formation
Condition
Hemophilia A
Study Arms / Comparison Groups
Hemophilia A
Description: Boys with Factor VIII coagulant activity less than or equal to 1%.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
42
Start Date
September 2014
Completion Date
December 2016
Primary Completion Date
December 2015
Eligibility Criteria
Inclusion Criteria: - documented circulating FVIII level of ≤1% - age 3 - 20 years - may be on primary or secondary prophylaxis - granting of informed consent Exclusion Criteria: - measurable inhibitor level at the time of enrollment - ingestion of aspirin/supplement known to influence platelet function within 14 days of blood sampling, or ibuprofen within 3 days
Gender
Male
Ages
3 Years - 20 Years
Accepts Healthy Volunteers
No
Contacts
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Location Countries
Canada
Location Countries
Canada
Administrative Informations
NCT ID
NCT02225483
Organization ID
H2013:304
Responsible Party
Sponsor
Study Sponsor
CancerCare Manitoba
Collaborators
The Hospital for Sick Children
Study Sponsor
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Verification Date
January 2016