Brief Title
Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy
Official Title
Effects of Preoperative Immunonutrition on Infectious Complication and Th1/Th2 Differentiation in Patients Undergoing Hepatectomy
Brief Summary
The purpose of this study is to determine whether preoperative immunonutrition is effective on infectious complication and Th1/Th2 differentiation in patients with major hepatectomy.
Detailed Description
The investigators reported that preoperative immunonutrition improve the incidence of postoperative infectious complication in patients after hepatectomy, and modulation of Th1/Th2 differentiation may play important roles in this effect. Object of this study is to investigate the effects of preoperative immunonutrition on incidence of postoperative infectious complication, and Th1/Th2 balance after hepatectomy.
Study Phase
Phase 4
Study Type
Interventional
Primary Outcome
postoperative infectious complication
Secondary Outcome
plasma IL-6, CRP, Th1/Th2 balance
Condition
Bile Duct Cancer
Intervention
Oral IMPACT
Study Arms / Comparison Groups
group A
Description: preoperative immunonutrition
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Dietary Supplement
Estimated Enrollment
40
Start Date
May 2009
Completion Date
March 2014
Primary Completion Date
March 2014
Eligibility Criteria
Inclusion Criteria: - hepatectomy Exclusion Criteria: - age younger than 18 years - ongoing infection - gastrointestinal obstruction - respiratory dysfunction - cardiac dysfunction - hepatic dysfunction - renal failure - history of recent immunosuppressive or immunological disease - preoperative evidence of widespread metastatic disease
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Katsunori Furukawa, MD, ,
Location Countries
Japan
Location Countries
Japan
Administrative Informations
NCT ID
NCT01256047
Organization ID
furukawa2009-2
Responsible Party
Principal Investigator
Study Sponsor
Chiba University
Study Sponsor
Katsunori Furukawa, MD, Study Director, Chiba University
Verification Date
February 2020