Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy

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Brief Title

Effects of Preoperative Immunonutrition in Patients Undergoing Hepatectomy

Official Title

Effects of Preoperative Immunonutrition on Infectious Complication and Th1/Th2 Differentiation in Patients Undergoing Hepatectomy

Brief Summary

      The purpose of this study is to determine whether preoperative immunonutrition is effective
      on infectious complication and Th1/Th2 differentiation in patients with major hepatectomy.

Detailed Description

      The investigators reported that preoperative immunonutrition improve the incidence of
      postoperative infectious complication in patients after hepatectomy, and modulation of
      Th1/Th2 differentiation may play important roles in this effect.

      Object of this study is to investigate the effects of preoperative immunonutrition on
      incidence of postoperative infectious complication, and Th1/Th2 balance after hepatectomy.

Study Phase

Phase 4

Study Type

Interventional

Primary Outcome

postoperative infectious complication

Secondary Outcome

 plasma IL-6, CRP, Th1/Th2 balance

Condition

Bile Duct Cancer

Intervention

Oral IMPACT

Study Arms / Comparison Groups

 group A
Description:  preoperative immunonutrition

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Dietary Supplement

Estimated Enrollment

40

Start Date

May 2009

Completion Date

March 2014

Primary Completion Date

March 2014

Eligibility Criteria

        Inclusion Criteria:

          -  hepatectomy

        Exclusion Criteria:

          -  age younger than 18 years

          -  ongoing infection

          -  gastrointestinal obstruction

          -  respiratory dysfunction

          -  cardiac dysfunction

          -  hepatic dysfunction

          -  renal failure

          -  history of recent immunosuppressive or immunological disease

          -  preoperative evidence of widespread metastatic disease

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Katsunori Furukawa, MD, ,

Location Countries

Japan

Location Countries

Japan

Administrative Informations

NCT ID

NCT01256047

Organization ID

furukawa2009-2

Responsible Party

Principal Investigator

Study Sponsor

Chiba University

Study Sponsor

Katsunori Furukawa, MD, Study Director, Chiba University

Verification Date

February 2020