Brief Title
DNA Methylation Biomarker for Diagnosis of Cholangiocarcinoma in Patients With Bile Duct Stricture
Official Title
DNA Methylation Biomarker in Biliary Brush Sample for Diagnosis of Cholangiocarcinoma in Patients With Bile Duct Stricture
Brief Summary
DNA methylation biomarker for diagnosis of cholangiocarcinoma in patients with bile duct stricture has high sensitivity and specificity compared with cytology from the brush specimens
Detailed Description
The methylation of HOXA1, NEUROG1 were used to determine cholangiocarcinoma from brushed biliary samples. However, the sensitivity and specificity of this test for cholangiocarcinoma is still required.
Study Type
Interventional
Primary Outcome
The methylation of HOXA1, NEUROG1 were determined in brushed biliary samples from patients with CCAs compared to those of nonmalignant bile duct stricture
Secondary Outcome
Sensitivity, specificity of DNA methylation for diagnosis of cholangiocarcinoma
Condition
Cholangiocarcinoma
Intervention
Control
Study Arms / Comparison Groups
Control
Description: Brushed biliary samples from a known case of benign biliary stricture were sent for DNA Methylation Biomarker test and cell cytology
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Diagnostic Test
Estimated Enrollment
67
Start Date
January 1, 2016
Completion Date
December 31, 2019
Primary Completion Date
December 31, 2019
Eligibility Criteria
Inclusion Criteria: - Age more than 18 year old - Patients had biliary stricture from cholangiocarcinoma and benign stricture Exclusion Criteria: - Pregnancy - Patient had other malignancy
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Varayu Prachayakul, ,
Location Countries
Thailand
Location Countries
Thailand
Administrative Informations
NCT ID
NCT04568512
Organization ID
149/2559
Responsible Party
Sponsor
Study Sponsor
Mahidol University
Study Sponsor
Varayu Prachayakul, Principal Investigator, Mahidol University
Verification Date
September 2020