A Clinical Trial to Evaluate Safety and Efficacy of Endovascualr Denervation in Treatment of Cancer Pain
A Prospective, Multicenter, Self-Control Clinical Trial to Evaluate Safety and Efficacy of Endovascular Denervation in Treatment of Cancer Pain
A prospective, multicenter, self-control clinical trial aim to enroll 110 patients suffered from upper abdominal (liver, pancreas, stomach, etc.) cancers . Patients who have taken at least one opioid drug for pain for two weeks and still have a VAS pain scale greater than 6 will receive endovascular denervation (EDN). They will be followed up for 3 months. The VAS scales, quantity of analgesics as represented by morphine equivalent and quality of life scores will be compared before and after EDN. Safety parameters such as arterial deformation, embolism, infection, liver and kidney functions will also be monitored.
Visual Analog Scale Changes over the time
Morphine Equivalent Changes over the time
Study Arms / Comparison Groups
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
July 15, 2019
July 15, 2021
Primary Completion Date
July 15, 2021
Inclusion Criteria: - Males or females with ages of 25 to 75; - Clinically diagnosed as primary or secondary upper abdominal cancers (liver, pancreas, stomach, etc); - Patients who have taken at least one opioid drug for pain for two weeks and still have VAS pain scale 》6; - Expected lifetime 》4 months; - Agrees to take part in the trial and signs the written, informed consent. Exclusion Criteria: - Women who are pregnant, or breast feeding, or having pregancy plan; - Bleeding tendency or other coagulation related diseases; - Acute or severe systemic infection; - Past history of receving denervation procedure in aorta; - No plans for surgical or interventional procedures in 3 months; - History of stroke or TIA within 2 weeks; - Acute coronary events within 2 weeks; - Other conditions that deem unsuitable for the procedure, in the opinions of investigators.
25 Years - 75 Years
Accepts Healthy Volunteers
Gao-Jun Teng, MD, 86-21-5486-8731, [email protected]
Shanghai Golden Leaf MedTec Co. Ltd
Gao-Jun Teng, MD, Study Chair, Zhongda Hospital