The Pathophysiology of Tourette Syndrome: a Multimodal Study

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Brief Title

The Pathophysiology of Tourette Syndrome: a Multimodal Study

Official Title

fMRI Study on Iron Deficiency in the Pathological Mechanism of Tourette Syndrome

Brief Summary

      The purpose of this study is to characterize the functional and anatomical connectivity
      changes in Tourette syndrome and its relation with iron deficiency.

Detailed Description

      Tourette syndrome (TS) is a childhood-onset chronic neuropsychiatric disorder with an
      increasing prevalence (range 0.05-3%).The investigators previous study showed that lower
      serum ferritin and iron levels in children with Tourette syndrome than in healthy children.
      The exact mechanism explaining how iron deficiency contributes to the pathophysiology of TS
      is unclear.One question is whether or not peripheral iron deficiency in children with
      Tourette syndrome can inflence the brain extrapyramid structure and resting state brain
      function？Another question is how well peripheral iron indices correlate with central iron
      content？ The third question is for TS children with peripheral iron deficiency, oral iron
      supplement (5mg/Kg/d) at least 8 weeks, the peripheral iron indicies return to normal levels,
      how the brain iron contents and the relative structure and brain function change?, To test
      the above-metioned hypothesis, functional magnetic resonance imaging (fMRI) , diffusion
      tensor imaging (DTI) and susceptibility weighted imaging (SWI) are applied to investigate the
      volume change of extrapyramid structure such as caudate nucleus and putamen, resting-state
      brain function and brain iron content before and after oral iron supplementation in TS
      children with peripheral iron deficiency, TS children with peripheral normal iron levels and
      normal healthy controls. The investigators hope to confirm that iron deficiency may play a
      causal role in the dopamine metabolism and it helps to further explore the pathophysiology of
      Tourette syndrome and also would contribute to significant advance in the therapeutic option
      for TS children with peripheral iron deficiency.

Study Type

Observational [Patient Registry]

Primary Outcome

Amplitude of low frequency fluctuation of BOLD signal in Tourette syndrome and its relation with iron deficiency

Secondary Outcome

 Brain iron levels in Tourette syndrome

Condition

Tourette Syndrome

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

40

Start Date

December 2013

Completion Date

April 2017

Primary Completion Date

November 2016

Eligibility Criteria

        Inclusion Criteria:

          -  6-12 years old

          -  Characterized by vocal tic and muscle twitch

          -  No positive signs was found through neurological examination, no significant
             psychomotor retardation,

        Exclusion Criteria:

          -  Hepatolenticular degeneration

          -  Rheumatic chorea

          -  Myoclonic epilepsy

          -  History of mental disease or brain trauma

Gender

All

Ages

6 Years - 12 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Jianhua Feng, Doctor, ,

Location Countries

China

Location Countries

China

Administrative Informations

NCT ID

NCT02497807

Organization ID

SAHZJU_CCBD_TouretteS

Responsible Party

Principal Investigator

Study Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Study Sponsor

Jianhua Feng, Doctor, Principal Investigator, Second affiliated hospital,zhejiang University,school of medicine,

Verification Date

April 2016