Apathy in Tourette Syndrome and Changes in Quality of Life

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Brief Title

Apathy in Tourette Syndrome and Changes in Quality of Life

Official Title

Apathy in Tourette Syndrome and Changes in Quality of Life - Effect of Medications

Brief Summary

      Tourette syndrome is a complex neuropsychological disorder with both motor and vocal tics
      associated with multiple psychological co-morbidities. Apathy has not been widely studied in
      patients with Tourette syndrome. Apathy can result in decrease in self-care and disease
      control. In this study investigators will compare the occurrence of apathy in the adolescent
      Tourette syndrome population (at the UF center for movement disorders and Neurorestoration)
      to an age and gender matched control population. Investigators will also assess the role of
      commonly used medications in the Tourette population (neuroleptics and selective serotonin
      receptor inhibitors) in the occurrence of apathy.

Detailed Description

      Tourette syndrome(TS) is a complex neuropsychological disorder with both motor and vocal tics
      associated with multiple psychological co-morbidities. The most common co-morbidities include
      obsessive compulsive disorder (OCD), attention deficit and hyperactivity disorder (ADHD) and
      depression. Apathy has not been extensively studied in the Tourette syndrome population.
      Apathy is currently defined as reduced motivation, with symptoms in at least two of three
      domains of reduced initiative, reduced interest and/or reduced emotional responsiveness. A
      study assessed the prevalence of apathy in multiple movement disorders and reported that
      apathy is much more common in disorders associated with slowed movements like Parkinson
      disease while less common in disorders with increased movements like Huntington disease and
      Tourette syndrome in adults. However, no apathy studies in adolescent patients with Tourette
      syndrome are published. Disengagement from treatment may affect health outcomes in other
      disease states. Apathy has significant effects on the quality of life and health outcomes in
      many patients. Apathy can be a direct manifestation of the neuropsychological process
      (intrinsic to the disease) or can be secondary to medication side effects most notably
      anti-dopaminergic agents and some reports of selective serotonin receptor inhibitors (SSRI).
      Further attention to the prevalence and impact of apathy in the adolescent Tourette syndrome
      population is needed to explore if this may be a factor influencing TS management and
      ultimately Quality of life (QOL). Multiple psychotropic medications are used in the
      management of tics as well as the psychological co-morbidities. How these medications affect
      apathy prevalence in Tourette syndrome patients is not known.

Study Type

Observational

Primary Outcome

Children's Motivation Scale

Secondary Outcome

 Yale Global Tic Severity Scale (YGTSS)

Condition

Tourette Syndrome

Intervention

Children's Motivation Scale

Study Arms / Comparison Groups

 Patients with Tourette Syndrome
Description:  The primary caregiver will be asked to fill the Children's motivation Scale. Other measures will be collected including a clinician filled Yale Global Tic Severity Scale (YGTSS) - severity score, Center for Epidemiological Studies Depression Scale for Children (CES-DC) and Gilles de la Tourette Syndrome Quality Of Life scale (GTS-QOL). Demographic data will also be collected for each study patient. Demographic data will also be collected for each study patient.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Other

Estimated Enrollment

38

Start Date

April 2016

Completion Date

April 2017

Primary Completion Date

March 2017

Eligibility Criteria

        Inclusion Criteria:

          -  Diagnosis: Tourette syndrome

          -  Age: 12-16 years

          -  Followed at the CMDNR

        Exclusion Criteria:

          -  History of cerebral palsy or traumatic brain injury

Gender

All

Ages

12 Years - 16 Years

Accepts Healthy Volunteers

No

Contacts

Wissam Deeb, ,

Location Countries

United States

Location Countries

United States

Administrative Informations

NCT ID

NCT02765178

Organization ID

IRB201500989

Responsible Party

Sponsor

Study Sponsor

University of Florida

Study Sponsor

Wissam Deeb, Principal Investigator, UF Center for Movement Disorders and Neurorestoration

Verification Date

July 2017