Brief Title
Neuropsychological Functioning Among Children With Tourret's Disorder and ADHD
Official Title
Neuropsychological Functioning, Symptomatology, and Social Adjustment Among Children With Tourret's Disorder, Attention-Deficit/Hyperactivity Disorder, and Comorbid Conditions.
Brief Summary
Tourette's disorder (TD) is a childhood-onset neuropsychiatric disorder, manifesting motor and vocal tics with increased likelihood of comorbid with attention-deficit/hyperactivity disorder (ADHD) and other psychiatric disorders. Literature documents the comorbid condition with ADHD predicts an increased functional deficit among individuals with ADHD. The information about neuropsychological functioning among individuals with TD adn/or ADHD is little in Asian population. This study aims to validate the diagnoses of TD, ADHD, and TD comorbid ADHD by symptomatology, neuropsychological measures, and social adjustment. This is a case-control study with a sample of 30 subjects with TD, 60 with ADHD, 30 with TD+ADHD, and 60 controls aged from 6 to 18. All subjects will receive comprehensive assessment including standard psychiatric diagnostic interviews using (K-SADS-E), behavioral assessments (SNAP-IV, CPRS:R-S, CTRS:R-S, CBCL, YBOCS, YGTSS), social adjustment (SAICA, GCAS), parenting (PBI, APGAR) and neuropsychological assessment (CPT, CANTAB, WISC-III). We anticipate that this study will provide the primitive data to validate the TD and ADHD using neuropsychological and clinical measures.
Study Type
Observational
Condition
Tourette Disorder
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
120
Start Date
January 2007
Completion Date
December 2007
Eligibility Criteria
Inclusion Criteria: - patients aged 8-16 without the diagnosis of ADHD, and/or Tourette's disorder - IQ > 80 - both children/adolescents and their parents consent to participate and have the ability to complete self-administered measures in this study Exclusion Criteria: - diagnosis of psychotic disorders, bipolar affective disorders, pervasive developmental disorder, seizure, or major physical disorders. - in addition, control subjects will be excluded from the control group if have a history of the following condition as defined by DSM-IV: ADHD, ODD, or CD in addition to the above exclusion criteria.
Gender
All
Ages
8 Years - 16 Years
Accepts Healthy Volunteers
No
Contacts
Susan Shur-Fen Gau, MD, PhD, ,
Location Countries
Taiwan
Location Countries
Taiwan
Administrative Informations
NCT ID
NCT00416091
Organization ID
9561706006
Secondary IDs
NTUH96- S558
Responsible Party
Sponsor
Study Sponsor
National Taiwan University Hospital
Study Sponsor
Susan Shur-Fen Gau, MD, PhD, Principal Investigator, National Taiwan University Hospital & College of Medicine
Verification Date
September 2008