Sensory Processing in Tourette Syndrome

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Brief Title

Sensory Processing in Tourette Syndrome

Official Title

Sensory Processing in Tourette Syndrome

Brief Summary

      The purpose of this study is to learn more about how patients with Tourette Syndrome deal
      with sensory stimuli in their environment such as bright lights, loud noises, physical
      sensations such as shirt tags, etcetera. We will compare responses of patients with Tourette
      Syndrome to those without Tourette Syndrome.

      The study aims to better characterize sensory processing abnormalities by sensory modality:
      The investigators will use a measuring tool based on Dunn's 1997 model of sensory processing,
      the Sensory Profile, which will allow the investigator to characterize both registration and
      response to external stimuli, as well as to delineate which sensory modalities are affected.
      Identifying which sensory modalities are most affected may guide future research into the
      pathophysiology of sensory processing abnormalities in TS.

      The investigators also aim to correlate sensory processing abnormalities with the presence of
      Obsessive Compulsive Disorder (OCD), Attention-deficit/hyperactivity disorder (ADHD) , and
      autism spectrum disorders.
    

Detailed Description

      While it is widely recognized that patients with tic and Tourette Syndrome (TS) experience
      heightened sensitivity to or abnormal processing of internal sensations, it has also been
      suggested that patients with tic and TS experience abnormal processing of external
      sensations/stimuli. While this sensitivity to external stimuli does not appear to trigger
      motor or vocal tics, it can significantly affect quality of life. These sensitivities can be
      a source of irritation, discomfort, and distraction that can be equally or more disruptive
      than vocal or motor tics. Heightened sensitivity to external stimuli or other abnormalities
      of external sensory processing have been identified in other neuropsychological disorders
      such as autism spectrum disorders, schizophrenia, traumatic brain injury, ADHD, and
      obsessive-compulsive disorder (OCD) . TS often presents with co-morbid diagnoses including
      attention-deficit and hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD)
      but it is not currently known whether sensitivity to external stimuli is due to a central
      processing abnormality common to these disorders.

      This study's objective is to use a variety of questionnaires to determine how external
      stimuli along with the presence of other disorders effect sensory processing.
    


Study Type

Observational


Primary Outcome

The Sensory Profile


Condition

Tourette Syndrome

Intervention

The Sensory Profile

Study Arms / Comparison Groups

 Patients with Tourette Syndrome
Description:  Questionnaires including the Sensory Profile or the Adult/Adolescent Sensory profile and Children's Yale-Brown Obsessive Compulsive Scale or Yale Global Tic Severity Scale will be administered. When time permits, the Children's Yale-Brown Obsessive Compulsive Scale or Yale-Brown Obsessive Compulsive Scale will also be administered. Demographic data will also be collected for each study patient.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

18

Start Date

August 2015

Completion Date

June 2, 2016

Primary Completion Date

January 2016

Eligibility Criteria

        Inclusion Criteria:

          -  Targeted study population includes patients diagnosed with Tourette Syndrome

          -  Patient of University of Florida Movement Disorders Center diagnosed with Tourette
             Syndrome by a movement disorder specialist, according to DSM IV diagnostic criteria

          -  Age 6-18

          -  Presence of parent or guardian able to provide consent in the case of minors

        Exclusion Criteria:

          -  Inability of patient or, in the case of minors, parent/guardian to provide informed
             consent

          -  Inability of designated person to complete questionnaires. In the case of patients'
             age 10 and younger, this would refer to the parent/guardian. In the case of patients
             older than 10, this could be either the patient or their parent/guardian
      

Gender

All

Ages

6 Years - 18 Years

Accepts Healthy Volunteers

No

Contacts

Irene Malaty, M.D., , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT02512406

Organization ID

IRB201400293


Responsible Party

Sponsor

Study Sponsor

University of Florida


Study Sponsor

Irene Malaty, M.D., Principal Investigator, University of Florida


Verification Date

April 2017