Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome

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Brief Title

Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome

Official Title

Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome

Brief Summary

      Repetitive transcranial stimulation (rTMS) of the posterior parietal cortex will be applied
      daily over five days in adult Gilles de la Tourette patients. This approach aims at reducing
      premonitory sensations believed to induce tics. Patients will be randomized to an active or
      placebo (sham) group in a crossover design.

Study Phase

Phase 2

Study Type

Interventional

Primary Outcome

Yale global tic severity scale (YTGSS)

Condition

Gilles de la Tourette Syndrome

Intervention

rTMS

Study Arms / Comparison Groups

 Stimulation
Description:  Repetitive transcranial stimulation of the posterior parietal cortex

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Device

Estimated Enrollment

5

Start Date

February 2010

Completion Date

September 2012

Primary Completion Date

September 2012

Eligibility Criteria

        Inclusion Criteria:

          -  Gilles de la Tourette syndrome as defined by DSM IV-R

          -  Yale Global Tics Severity Scale (YGTSS) score between 30 et 60

          -  Premonitory sensations (" urge to move ")

          -  Affiliated to the French social security regime

          -  Ability to give informed consent

        Exclusion Criteria:

          -  rTMS : epilepsy, craniotomy scar, pacemaker or neural stimulator, metal implants or
             foreign bodies, claustrophobia, pregnancy

          -  Cognitive impairment (MMS ≤ 24/30)

          -  Axis I disorders according to DSM IV-R : psychosis or history of psychosis, bipolar
             illness, major depressive disorder, addictions (except to nicotine)

          -  Impulse control disorders

          -  Other chronic debilitating illnesses

          -  Unability to give informed consent

          -  Participation in another clinical trial

Gender

All

Ages

18 Years - 70 Years

Accepts Healthy Volunteers

No

Contacts

Andreas Hartmann, MD, ,

Location Countries

France

Location Countries

France

Administrative Informations

NCT ID

NCT01043549

Organization ID

C08-46

Secondary IDs

2009-A00759-48

Responsible Party

Sponsor

Study Sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Study Sponsor

Andreas Hartmann, MD, Principal Investigator, Institut National de la Santé Et de la Recherche Médicale, France

Verification Date

February 2016