Brief Title
Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome
Official Title
Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome
Brief Summary
Repetitive transcranial stimulation (rTMS) of the posterior parietal cortex will be applied daily over five days in adult Gilles de la Tourette patients. This approach aims at reducing premonitory sensations believed to induce tics. Patients will be randomized to an active or placebo (sham) group in a crossover design.
Study Phase
Phase 2
Study Type
Interventional
Primary Outcome
Yale global tic severity scale (YTGSS)
Condition
Gilles de la Tourette Syndrome
Intervention
rTMS
Study Arms / Comparison Groups
Stimulation
Description: Repetitive transcranial stimulation of the posterior parietal cortex
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Device
Estimated Enrollment
5
Start Date
February 2010
Completion Date
September 2012
Primary Completion Date
September 2012
Eligibility Criteria
Inclusion Criteria: - Gilles de la Tourette syndrome as defined by DSM IV-R - Yale Global Tics Severity Scale (YGTSS) score between 30 et 60 - Premonitory sensations (" urge to move ") - Affiliated to the French social security regime - Ability to give informed consent Exclusion Criteria: - rTMS : epilepsy, craniotomy scar, pacemaker or neural stimulator, metal implants or foreign bodies, claustrophobia, pregnancy - Cognitive impairment (MMS ≤ 24/30) - Axis I disorders according to DSM IV-R : psychosis or history of psychosis, bipolar illness, major depressive disorder, addictions (except to nicotine) - Impulse control disorders - Other chronic debilitating illnesses - Unability to give informed consent - Participation in another clinical trial
Gender
All
Ages
18 Years - 70 Years
Accepts Healthy Volunteers
No
Contacts
Andreas Hartmann, MD, ,
Location Countries
France
Location Countries
France
Administrative Informations
NCT ID
NCT01043549
Organization ID
C08-46
Secondary IDs
2009-A00759-48
Responsible Party
Sponsor
Study Sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Study Sponsor
Andreas Hartmann, MD, Principal Investigator, Institut National de la Santé Et de la Recherche Médicale, France
Verification Date
February 2016