Role of Frontal Cortex in the Pathophysiology of Gilles de la Tourette Syndrome (GTS)

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Brief Title

Role of Frontal Cortex in the Pathophysiology of Gilles de la Tourette Syndrome (GTS)

Official Title

Role of Frontal Cortex in the Pathophysiology of Gilles de la Tourette Syndrome (GTS)

Brief Summary

      Tourette's syndrome (TS) is a debilitating and severe syndrome whose pathophysiology remains
      unclear.

      In order to precise the cortical regions involved in the generation of tics, investigators
      will realize an electroencephalogram (EEG) recording in the frontal cortex of TS patients in
      ecological conditions (EEG-holter). Activity changes will be correlated with event markers of
      tics and neurovegetative parameters. Statistical analyses will be compared between epochs of
      EEG recording with tics and without tics. The aim is to define the cortical regions involved
      in the genesis of tics in order to consider new targets for cortical stimulation.

Detailed Description

      Gilles de la Tourette syndrome (GTS) is a childhood-onset disorder characterized by the
      presence of multiple motor tics and at least one vocal tic often associated with psychiatric
      co-morbidity. The expression of tics range from brief, recurrent and non-rhythmic motor or
      vocal actions (simple tics) to complex motor or vocal sequences (complex tics). The
      pathophysiology of tics is not yet fully understood. Recent imaging data suggest that the
      pattern of functional connectivity in cortico-basal ganglia networks is disrupted in GTS
      patients and could reflect a defect in brain maturation. However, regions involved in the
      immediate genesis of tics remains unknown since it is difficult to capture on line the
      cortical changes associated with tic generation using imaging techniques due to moving
      artefacts. Moreover, tics are much more frequent in everyday life conditions than in the
      artificial conditions of a laboratory. The aim is to study cortical activity changes
      occurring before tic occurrence by using long duration recording of encephalographic activity
      (EEG) in ecological conditions through Holter EEG techniques (24h recordings). Recordings
      will be performed in 15 patients with a severe form of Tourette's syndromes. EEG changes will
      be correlated to event markers, voluntary monitored by patients or automatically recorded
      (accelerometers for motor tics). EEG epoch centered on tics will be compared to similar
      epochs without tics. The occurrence of tics will also be correlated with neurovegetative
      markers of emotions such as RR interval ECG variability and skin resistivity changes. The
      ultimate goal of this project is to define a potential therapeutic target of tics for chronic
      cortical stimulation.

Study Type

Interventional

Primary Outcome

Electroencephalogram (EEG) signal

Secondary Outcome

 Tic occurence

Condition

Tourette Syndrome

Intervention

Electroencephalographic recordings

Study Arms / Comparison Groups

 Electroencephalographic recordings
Description:  Electroencephalographic recordings

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Procedure

Estimated Enrollment

14

Start Date

February 2, 2018

Completion Date

March 3, 2020

Primary Completion Date

March 3, 2020

Eligibility Criteria

        Inclusion Criteria:

          -  Tourette's syndrome since at least 2 years

          -  Lack of psychiatric comorbidity of axis 1 (depression)

          -  Y-YSGT score > 20

          -  Social insurance in accordance with the french law

        Exclusion Criteria:

          -  Epilepsia

          -  Patient with an implanted medical device

          -  Severe mental or somatic disease

          -  Risk of suicide,

          -  Pregnant or breast feeding women

          -  Patient under "curatelle" or "tutelle"

          -  Patient hospitalized

        no social insurance

Gender

All

Ages

12 Years - 60 Years

Accepts Healthy Volunteers

No

Contacts

, ,

Location Countries

France

Location Countries

France

Administrative Informations

NCT ID

NCT03604510

Organization ID

CHUBX2016/41

Responsible Party

Sponsor

Study Sponsor

University Hospital, Bordeaux

Study Sponsor

, ,

Verification Date

April 2020