The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy

checkorphan
Learn more about:
Ectopic pregnancy
Related Clinical Trial
Medical Treatment in Ectopic Tubal Pregnancy Evaluation of Different Doses of Letrozole in Ectopic Pregnancy Evaluation of Ipsilateral Tubal Patency After Conservative Medical or Surgical Treatment. Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task Expectant Management of Ectopic Pregnancy Psychological Impact of Pregnancy of Unknown Location Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility Hysteroscopic Metroplasty in Unexplained Infertile Women With Dysmorphic Uterus Cornual Wedge Resection Outcome Pregnancies of Uncertain Location or Viability Research Randomized Population-Based Study on Chlamydia Trachomatis Screening Sonographic Assessment and Visualization of Ectopics in Emergency Medicine Kisspeptin Levels in Early Pregnancy RCT for Women With a Persisting Pregnancy of Unknown Location Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy Vitamin D in Ectopic Pregnancies Laparoscopic Tubal Preservation Surgery BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success The Correlation Between Uterine Endometrial Pattern and Ectopic Pregnancy Adnexal Mass After Methotrexate Treatment for Ectopic Pregnancies The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy Methotrexate Treatment for Ectopic Pregnancy Comparison of Two Different Approaches in the Surgical Treatment of Tubal Ectopic Pregnancy Two-Dose Methotrexate for Ectopic Pregnancy Ectopic Pregnancy Biomarkers The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy Are Serum Levels of Vascular Endothelial Growth Factor a Marker for the Early Diagnosis of Ectopic Pregnancy? Risk Factors of Ectopic Pregnancy Assessment of Biomarkers in Ectopic Pregnancy Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Brief Title

The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy

Official Title

The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy

Brief Summary

      The aim of this study is to :

        1. Use of the aromatase inhibitor( letrozole) for the treatment of ectopic pregnancy
           compared to methotrexate.

        2. Use of the Gnrh antagonist for the treatment of ectopic pregnancy compared to
           methotrexate.

Study Type

Interventional

Primary Outcome

determine efficacy of the aromatase inhibitor and Gnrh antagonist to achievement of resolution of ectopic pregnancy determined by serum hCG levels below laboratory immunoassay detection <15 IU/l.Results will be statistically analyzed,then evaluated .

Condition

Ectopic Pregnancy

Intervention

Methotrexate

Study Arms / Comparison Groups

 Methotrexate group
Description:

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Drug

Estimated Enrollment

120

Start Date

March 30, 2020

Completion Date

September 1, 2022

Primary Completion Date

March 1, 2022

Eligibility Criteria

        Inclusion Criteria:

          -  Patients who have undisturbed ectopic pregnancy .Who are:

               1. have no significant pain

               2. have an unruptured tubal ectopic pregnancy with an adnexal mass smaller than 35mm
                  with no visible heartbeat

               3. have a serum human chorionic gonadotropins level less than 1,500 IU/litre

               4. do not have an intrauterine pregnancy (as confirmed on an ultrasound scan) .

        Exclusion Criteria:

          1. An undisturbed ectopic pregnancy and significant pain

          2. An undisturbed ectopic pregnancy with an adnexal mass of 35 mm or larger

          3. An undisturbed ectopic pregnancy with a fetal heartbeat visible on an ultrasound scan

          4. An undisturbed ectopic pregnancy and a serum human chorionic gonadotropins level of
             5,000 IU/litre or more

          5. intrauterine pregnancy

Gender

Female

Ages

18 Years - 40 Years

Accepts Healthy Volunteers

No

Contacts

, 01095567589, [email protected]

Administrative Informations

NCT ID

NCT04308343

Organization ID

Aromatase inhibitor in ectopic

Responsible Party

Principal Investigator

Study Sponsor

Assiut University

Study Sponsor

, ,

Verification Date

March 2020