Ectopic Pregnancy Biomarkers

Learn more about:
Related Clinical Trial
Reproductive Outcomes After a Previous Episode of Tubal Ectopic Pregnancy in Patients Managed Expectantly and Surgically Relationship Between Ectopic Pregnancy and Thyroid Disorders Medical Treatment in Ectopic Tubal Pregnancy Evaluation of Different Doses of Letrozole in Ectopic Pregnancy Evaluation of Ipsilateral Tubal Patency After Conservative Medical or Surgical Treatment. Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task Expectant Management of Ectopic Pregnancy Psychological Impact of Pregnancy of Unknown Location Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility Hysteroscopic Metroplasty in Unexplained Infertile Women With Dysmorphic Uterus Cornual Wedge Resection Outcome Pregnancies of Uncertain Location or Viability Research Randomized Population-Based Study on Chlamydia Trachomatis Screening Sonographic Assessment and Visualization of Ectopics in Emergency Medicine Kisspeptin Levels in Early Pregnancy RCT for Women With a Persisting Pregnancy of Unknown Location Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy Vitamin D in Ectopic Pregnancies Laparoscopic Tubal Preservation Surgery BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success The Correlation Between Uterine Endometrial Pattern and Ectopic Pregnancy Adnexal Mass After Methotrexate Treatment for Ectopic Pregnancies The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy Methotrexate Treatment for Ectopic Pregnancy Comparison of Two Different Approaches in the Surgical Treatment of Tubal Ectopic Pregnancy Two-Dose Methotrexate for Ectopic Pregnancy Ectopic Pregnancy Biomarkers The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy Are Serum Levels of Vascular Endothelial Growth Factor a Marker for the Early Diagnosis of Ectopic Pregnancy? Risk Factors of Ectopic Pregnancy Assessment of Biomarkers in Ectopic Pregnancy Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Brief Title

Ectopic Pregnancy Biomarkers

Official Title

Serum Bank for Assessment of Markers of Ectopic Pregnancy

Brief Summary

      In an attempt to simplify the diagnosis of ectopic pregnancy, the researchers will
      investigate the presence of specific molecular markers of ectopic pregnancy. The
      quantification of these (and other proteins) will be performed using the Ciphergen Protein
      Chip system where serum is sampled with a high-throughput system. The patterns of these peaks
      will be compared for those with a diagnosis of ectopic pregnancy and normal pregnancy. Later
      goals of the research will be to identify the actual proteins that correspond to the peaks
      which discriminate between the two clinical entitles. The goal is to identify a unique
      protein pattern or protein peak to distinguish a normal intrauterine pregnancy from that of
      an ectopic implanted gestation.
    



Study Type

Observational




Condition

Ectopic Pregnancy



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

1306

Start Date

June 2000

Completion Date

November 2013

Primary Completion Date

November 2013

Eligibility Criteria

        Inclusion Criteria:

          -  Reproductive-aged women

          -  Currently pregnant based on serum human chorionic gonadotropin level

          -  Present for care for pregnancy due to vaginal bleeding and/or pelvic cramping

          -  Final diagnosis of one of the following:

               1. Live intrauterine pregnancy through 14 weeks, diagnosed by ultrasound
                  demonstrating fetal heart motion

               2. Diagnosed ectopic pregnancy

               3. Ultrasound confirmation of a nonviable gestation (less 14 weeks) such as an
                  anembryonic gestation or a fetal demise

        Exclusion Criteria:

          -  None
      

Gender

Female

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Kurt T Barnhart, MD, MSCE, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT00194168

Organization ID

705016

Secondary IDs

RRU002

Responsible Party

Sponsor

Study Sponsor

University of Pennsylvania

Collaborators

 Bill and Melinda Gates Foundation

Study Sponsor

Kurt T Barnhart, MD, MSCE, Principal Investigator, University of Pennsylvania


Verification Date

August 2016