Ectopic Pregnancy Biomarkers

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Brief Title

Ectopic Pregnancy Biomarkers

Official Title

Serum Bank for Assessment of Markers of Ectopic Pregnancy

Brief Summary

      In an attempt to simplify the diagnosis of ectopic pregnancy, the researchers will
      investigate the presence of specific molecular markers of ectopic pregnancy. The
      quantification of these (and other proteins) will be performed using the Ciphergen Protein
      Chip system where serum is sampled with a high-throughput system. The patterns of these peaks
      will be compared for those with a diagnosis of ectopic pregnancy and normal pregnancy. Later
      goals of the research will be to identify the actual proteins that correspond to the peaks
      which discriminate between the two clinical entitles. The goal is to identify a unique
      protein pattern or protein peak to distinguish a normal intrauterine pregnancy from that of
      an ectopic implanted gestation.

Study Type



Ectopic Pregnancy


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment


Start Date

June 2000

Completion Date

November 2013

Primary Completion Date

November 2013

Eligibility Criteria

        Inclusion Criteria:

          -  Reproductive-aged women

          -  Currently pregnant based on serum human chorionic gonadotropin level

          -  Present for care for pregnancy due to vaginal bleeding and/or pelvic cramping

          -  Final diagnosis of one of the following:

               1. Live intrauterine pregnancy through 14 weeks, diagnosed by ultrasound
                  demonstrating fetal heart motion

               2. Diagnosed ectopic pregnancy

               3. Ultrasound confirmation of a nonviable gestation (less 14 weeks) such as an
                  anembryonic gestation or a fetal demise

        Exclusion Criteria:

          -  None




N/A - N/A

Accepts Healthy Volunteers



Kurt T Barnhart, MD, MSCE, , 

Location Countries

United States

Location Countries

United States

Administrative Informations



Organization ID


Secondary IDs


Responsible Party


Study Sponsor

University of Pennsylvania


 Bill and Melinda Gates Foundation

Study Sponsor

Kurt T Barnhart, MD, MSCE, Principal Investigator, University of Pennsylvania

Verification Date

August 2016