Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy

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Brief Title

Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy


Brief Summary

      Patients who have doubt for ectopic pregnancy will be enrolled for our study. These patients
      will be determined with using irregular increased human chorionic gonadotropin (beta-HCG)
      results and no embryo reported ultrasonography results. Plasma and cervical fluid samples
      will be taken from these patients and axonemal dynein heavy chain 5 and creatine kinase
      levels of samples will be compared between patients who have doubt for ectopic pregnancy and
      patients who have intrauterine pregnancy. Concentration of these proteins in samples will be
      evaluated. If any difference will be found between groups in favour of ectopic pregnancy,
      these results might be interpreted as these proteins useful for early detecting of the
      ectopic pregnancy.
    



Study Type

Observational


Primary Outcome

Concentration of Axonemal Dynein Heavy Chain 5


Condition

Ectopic Pregnancy

Intervention

Collecting cervical liquid and sera samples

Study Arms / Comparison Groups

 Doubt for ectopic pregnancy group
Description:  This group participants have doubt for ectopic pregnancy in terms of beta-HCG pregnancy follow-up results and ultrasonography results.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

85

Start Date

September 2016

Completion Date

November 2018

Primary Completion Date

June 2018

Eligibility Criteria

        Inclusion Criteria:

          -  Doubted ectopic pregnancy

          -  Without any finding about intrauterine pregnancy in ultrasonography results

          -  Without any vaginal bleeding

          -  Having irregular pregnancy test results

          -  Beta-HCG results should be at least upper than 100 milli-International unit (mIU/ml)

          -  Having fist trimester pregnancy for intrauterine pregnancy group

          -  Without any emergency findings

        Exclusion Criteria:

          -  Doubted incomplete abortion

          -  Having vaginal bleeding

          -  Having ultrasound results which include intrauterine embryo report

          -  Having lower than 100 mIU/ml beta-HCG results

          -  Without fetal heart rate in intrauterine pregnancy group

          -  Having older than fist trimester pregnancy for intrauterine pregnancy group

          -  Having emergency findings
      

Gender

Female

Ages

18 Years - 45 Years

Accepts Healthy Volunteers

No

Contacts

, , 

Location Countries

Turkey

Location Countries

Turkey

Administrative Informations


NCT ID

NCT02995356

Organization ID

2.101.2015.0076


Responsible Party

Principal Investigator

Study Sponsor

Ege University


Study Sponsor

, , 


Verification Date

March 2019