Medical Treatment in Ectopic Tubal Pregnancy

Learn more about:
Related Clinical Trial
Reproductive Outcomes After a Previous Episode of Tubal Ectopic Pregnancy in Patients Managed Expectantly and Surgically Relationship Between Ectopic Pregnancy and Thyroid Disorders Medical Treatment in Ectopic Tubal Pregnancy Evaluation of Different Doses of Letrozole in Ectopic Pregnancy Evaluation of Ipsilateral Tubal Patency After Conservative Medical or Surgical Treatment. Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task Expectant Management of Ectopic Pregnancy Psychological Impact of Pregnancy of Unknown Location Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility Hysteroscopic Metroplasty in Unexplained Infertile Women With Dysmorphic Uterus Cornual Wedge Resection Outcome Pregnancies of Uncertain Location or Viability Research Randomized Population-Based Study on Chlamydia Trachomatis Screening Sonographic Assessment and Visualization of Ectopics in Emergency Medicine Kisspeptin Levels in Early Pregnancy RCT for Women With a Persisting Pregnancy of Unknown Location Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy Vitamin D in Ectopic Pregnancies Laparoscopic Tubal Preservation Surgery BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success The Correlation Between Uterine Endometrial Pattern and Ectopic Pregnancy Adnexal Mass After Methotrexate Treatment for Ectopic Pregnancies The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy Methotrexate Treatment for Ectopic Pregnancy Comparison of Two Different Approaches in the Surgical Treatment of Tubal Ectopic Pregnancy Two-Dose Methotrexate for Ectopic Pregnancy Ectopic Pregnancy Biomarkers The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy Are Serum Levels of Vascular Endothelial Growth Factor a Marker for the Early Diagnosis of Ectopic Pregnancy? Risk Factors of Ectopic Pregnancy Assessment of Biomarkers in Ectopic Pregnancy Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Brief Title

Medical Treatment in Ectopic Tubal Pregnancy

Official Title

Treatment Success With Two Doses of Methotrexate vs Single Dose of Methotrexate in Ectopic Tubal Pregnancy

Brief Summary

      Ectopic pregnancy (EP) is estimated to be responsible for approximately 20% of all
      pregnancy-related mortality and 46% early pregnancy mortality.1 Hemodynamically stable women
      with EP are frequently managed with methotrexate (MTX) while multiple protocols like fixed
      multiple doses, single-dose as well as two-dose regimens have been in practice for treating
      EP, but no consensus exists regarding the optimum dosage regimen.

Detailed Description

      Literature reports multiple dosage regimens of MTX to be associated with increased rates of
      side effects. Single dose protocol has good compliance and fewer side effects but is linked
      with lower success rates in comparison to multiple dose protocols.

      A new treatment protocol involving "two-doses" of MTX for medical management of EP was
      introduced in 2007 but most of the research conducted so far has been retrospective in nature
      and limitations in study designs. No such study in recent years has been done in Pakistan to
      compare the success and safety of single-dose and two-dose MTX protocols so this study was
      planned to compare the success rates and safety of two-doses of MTX versus single dose of MTX
      in tubal EP.

Study Type


Primary Outcome

success rate

Secondary Outcome

 frequency of Side-effects of treatment


Ectopic Pregnancy



Study Arms / Comparison Groups

 single-dose group
Description:  Women in single-dose group were administered a single-dose of intramuscular methotrexate as 50 mg/m2 on day-zero (the start of treatment).


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

January 1, 2020

Completion Date

July 30, 2021

Primary Completion Date

July 30, 2021

Eligibility Criteria

        Inclusion Criteria:

          -  Diagnosis of tubal ectopic pregnancy.

          -  Pre-treatment beta-human chorionic gonadotrophin (β-hCG) level below 1500 mIU/ml.

          -  Gestational sac with largest diameter as 4cm.

          -  Willing to take methotrexate treatment.

          -  Willing to follow up.

        Exclusion Criteria:

          -  Heterotrophic pregnancy

          -  Persistent tubal pregnancy

          -  Embryonic cardiac motion

          -  Suspected tubal rupture

          -  Past history of harmful effects of methotrexate treatment on organ functions.




20 Years - 35 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers


Rashida Parveen, FCPS, , 

Location Countries


Location Countries


Administrative Informations



Organization ID


Responsible Party

Principal Investigator

Study Sponsor

Nishtar Medical University

Study Sponsor

Rashida Parveen, FCPS, Principal Investigator, Nishtar Medical University

Verification Date

January 2022