Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Learn more about:
Related Clinical Trial
Reproductive Outcomes After a Previous Episode of Tubal Ectopic Pregnancy in Patients Managed Expectantly and Surgically Relationship Between Ectopic Pregnancy and Thyroid Disorders Medical Treatment in Ectopic Tubal Pregnancy Evaluation of Different Doses of Letrozole in Ectopic Pregnancy Evaluation of Ipsilateral Tubal Patency After Conservative Medical or Surgical Treatment. Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task Expectant Management of Ectopic Pregnancy Psychological Impact of Pregnancy of Unknown Location Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility Hysteroscopic Metroplasty in Unexplained Infertile Women With Dysmorphic Uterus Cornual Wedge Resection Outcome Pregnancies of Uncertain Location or Viability Research Randomized Population-Based Study on Chlamydia Trachomatis Screening Sonographic Assessment and Visualization of Ectopics in Emergency Medicine Kisspeptin Levels in Early Pregnancy RCT for Women With a Persisting Pregnancy of Unknown Location Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy Vitamin D in Ectopic Pregnancies Laparoscopic Tubal Preservation Surgery BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success The Correlation Between Uterine Endometrial Pattern and Ectopic Pregnancy Adnexal Mass After Methotrexate Treatment for Ectopic Pregnancies The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy Methotrexate Treatment for Ectopic Pregnancy Comparison of Two Different Approaches in the Surgical Treatment of Tubal Ectopic Pregnancy Two-Dose Methotrexate for Ectopic Pregnancy Ectopic Pregnancy Biomarkers The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy Are Serum Levels of Vascular Endothelial Growth Factor a Marker for the Early Diagnosis of Ectopic Pregnancy? Risk Factors of Ectopic Pregnancy Assessment of Biomarkers in Ectopic Pregnancy Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Brief Title

Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Official Title

Retrospective Cohort Study of Increased Risk of Ectopic Pregnancy Associated With Marked Variation of Estradiol During the Early Luteal Phase and High Progesterone on hCG Day in IVF

Brief Summary

      This study evaluates the increased risk of ectopic pregnancy associated with marked variation
      of estradiol during the early luteal phase and high progesterone on hCG day in IVF.
    

Detailed Description

      This is a retrospective cohort study of 578 patients who had no risk of EP (672 fresh
      transfer IVF cycles) between January 2005 and December 2014. Few studies have reported the
      relation between hormonal levels and ectopic pregnancy (EP) in IVF. Investigators describe EP
      incidence according to estradiol (E2) and progesterone (P4) levels on hCG day and seven days
      later (hCG+7) or their variation between both days.
    


Study Type

Observational


Primary Outcome

Ectopic pregnancy rate


Condition

Ectopic Pregnancy

Intervention

Analysis of Ectopic Pregnancy incidence

Study Arms / Comparison Groups

 First quartile
Description:  No drugs are administered. It is an observational study. Collect retrospectively data.Analysis of Ectopic Pregnancy incidence through Estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7).

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

578

Start Date

January 2005

Completion Date

May 2016

Primary Completion Date

May 2016

Eligibility Criteria

        Inclusion Criteria:

          -  Normal Fallopian tubes in HSG and /or laparoscopy

          -  Normal Uterus: Abscence of myomas and Müllerian anomalies .

        Exclusion Criteria:

          -  Previous Ectopic Pregnancy .

          -  Recurrent Abortion .

          -  Tubal Factor : pelvic inflammatory disease, Hydrosalpinx

          -  Previous abdominal surgery (except laparoscopy) .

          -  Prior Peritonitis

          -  Smoking (at least 1 cigarette/day) .
      

Gender

Female

Ages

25 Years - 45 Years

Accepts Healthy Volunteers

No

Contacts

Elkin Muñoz, , 



Administrative Informations


NCT ID

NCT02793089

Organization ID

1409-VGO-059-EM


Responsible Party

Sponsor

Study Sponsor

IVI Vigo

Collaborators

 Instituto Valenciano de Infertilidad, IVI VALENCIA

Study Sponsor

Elkin Muñoz, Principal Investigator, IVI Vigo


Verification Date

May 2016