Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

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Brief Title

Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Official Title

Retrospective Cohort Study of Increased Risk of Ectopic Pregnancy Associated With Marked Variation of Estradiol During the Early Luteal Phase and High Progesterone on hCG Day in IVF

Brief Summary

      This study evaluates the increased risk of ectopic pregnancy associated with marked variation
      of estradiol during the early luteal phase and high progesterone on hCG day in IVF.

Detailed Description

      This is a retrospective cohort study of 578 patients who had no risk of EP (672 fresh
      transfer IVF cycles) between January 2005 and December 2014. Few studies have reported the
      relation between hormonal levels and ectopic pregnancy (EP) in IVF. Investigators describe EP
      incidence according to estradiol (E2) and progesterone (P4) levels on hCG day and seven days
      later (hCG+7) or their variation between both days.

Study Type


Primary Outcome

Ectopic pregnancy rate


Ectopic Pregnancy


Analysis of Ectopic Pregnancy incidence

Study Arms / Comparison Groups

 First quartile
Description:  No drugs are administered. It is an observational study. Collect retrospectively data.Analysis of Ectopic Pregnancy incidence through Estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7).


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

January 2005

Completion Date

May 2016

Primary Completion Date

May 2016

Eligibility Criteria

        Inclusion Criteria:

          -  Normal Fallopian tubes in HSG and /or laparoscopy

          -  Normal Uterus: Abscence of myomas and Müllerian anomalies .

        Exclusion Criteria:

          -  Previous Ectopic Pregnancy .

          -  Recurrent Abortion .

          -  Tubal Factor : pelvic inflammatory disease, Hydrosalpinx

          -  Previous abdominal surgery (except laparoscopy) .

          -  Prior Peritonitis

          -  Smoking (at least 1 cigarette/day) .




25 Years - 45 Years

Accepts Healthy Volunteers



Elkin Muñoz, , 

Administrative Informations



Organization ID


Responsible Party


Study Sponsor

IVI Vigo


 Instituto Valenciano de Infertilidad, IVI VALENCIA

Study Sponsor

Elkin Muñoz, Principal Investigator, IVI Vigo

Verification Date

May 2016