Evaluation of Ipsilateral Tubal Patency After Conservative Medical or Surgical Treatment.

Learn more about:
Related Clinical Trial
Reproductive Outcomes After a Previous Episode of Tubal Ectopic Pregnancy in Patients Managed Expectantly and Surgically Relationship Between Ectopic Pregnancy and Thyroid Disorders Medical Treatment in Ectopic Tubal Pregnancy Evaluation of Different Doses of Letrozole in Ectopic Pregnancy Evaluation of Ipsilateral Tubal Patency After Conservative Medical or Surgical Treatment. Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task Expectant Management of Ectopic Pregnancy Psychological Impact of Pregnancy of Unknown Location Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility Hysteroscopic Metroplasty in Unexplained Infertile Women With Dysmorphic Uterus Cornual Wedge Resection Outcome Pregnancies of Uncertain Location or Viability Research Randomized Population-Based Study on Chlamydia Trachomatis Screening Sonographic Assessment and Visualization of Ectopics in Emergency Medicine Kisspeptin Levels in Early Pregnancy RCT for Women With a Persisting Pregnancy of Unknown Location Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy Vitamin D in Ectopic Pregnancies Laparoscopic Tubal Preservation Surgery BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success The Correlation Between Uterine Endometrial Pattern and Ectopic Pregnancy Adnexal Mass After Methotrexate Treatment for Ectopic Pregnancies The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy Methotrexate Treatment for Ectopic Pregnancy Comparison of Two Different Approaches in the Surgical Treatment of Tubal Ectopic Pregnancy Two-Dose Methotrexate for Ectopic Pregnancy Ectopic Pregnancy Biomarkers The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy Are Serum Levels of Vascular Endothelial Growth Factor a Marker for the Early Diagnosis of Ectopic Pregnancy? Risk Factors of Ectopic Pregnancy Assessment of Biomarkers in Ectopic Pregnancy Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Brief Title

Evaluation of Ipsilateral Tubal Patency After Conservative Medical or Surgical Treatment.

Official Title

Evaluation of Ipsilateral Tubal Patency After Conservative Medical or Surgical Treatment in Uncomplicated Ectopic Pregnancy, "Hospital General", Angola 2021-2022

Brief Summary

      Ectopic Pregnancy is an entity in which a fertilized ovum is implanted outside its normal
      place, is considered a public health problem worldwide and is one of the main causes of
      maternal mortality in the first trimester. The availability of high sensitivity methods of
      detection of gonadotrophins and the use of high resolution transvaginal ultrasonography have
      allowed an earlier diagnosis of the same, enabling less aggressive treatments such as the use
      of parenteral MTX, with the intention of avoiding mutilating surgical treatment , preserving
      the tube and eventually improving future fertility expectations. The surgical treatment is of
      choice, this can be laparoscopically or by laparotomy. In this case, we need to preserve
      fertility, the most indicated is linear salpingostomy; In spite of the existence other

Detailed Description

      The EP constitutes a frequent obstetric emergency in Angola and the province of Benguela is
      not exempt from this health problem. Every day we see women with this pathology, to which,
      most of them, they undergo a mutilating surgical treatment (salpingectomy) that impedes their
      future reproductive capacity. The procreation in the African continent and especially in
      Angola, has great social and family implications that can reach the breaking of marriages and
      family (broadcast and study of the Public Television of Angola in the program "Na lente" no
      year 2018 Taking into account the importance of procreation in the welfare and stability of
      the marital relationship.Main Objectiv: To demonstrate the non-inferiority of conservative
      treatment with MTX in ipsilateral tubal patency after an uncomplicated ectopic pregnancy
      compared with surgical treatment with linear salpingostomy in the Hospital General, Angola

Study Type


Primary Outcome

Incidence of Ipsilateral tubal patency

Secondary Outcome

 Incidence of Achieve the gestation and the culmination.


Ectopic Pregnancy


Medical treatment

Study Arms / Comparison Groups

 Medical treatment
Description:  By administering a single intramuscular dose of 50mg / m2 / Sc of Methotrexate.


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

August 17, 2021

Completion Date

August 17, 2023

Primary Completion Date

August 17, 2022

Eligibility Criteria

        Inclusion Criteria:

        Patient presenting with Ectopic Pregnancy, associated with quantitative titers of βHCG ≥
        100 mUI / ml, without intrauterine gestational sac.

        Patient presenting uncomplicated Ectopic Pregnancy with an adnexal mass diameter ≤4 cm
        diagnosed by abdominal and / or transvaginal ultrasonography.

        Absence of heartbeat. No toxicity to MTX. Normal laboratory tests (blood count,
        coagulogram, liver and kidney function). Hemodynamic stability.

        Exclusion Criteria:

          -  Complicated Ectopic Pregnancy.

          -  Ectopic pregnancy is out of the tuba on ultrasound

          -  Patients with Immunosuppression.

          -  Allergy to MTX.

          -  Patients with Active Respiratory Disease, Blood Dyspasia, Peptic Ulcer, Renal
             Insufficiency and Hepatic Insufficiency.

          -  Do not accept to participate in the study.




18 Years - 35 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers


Moreno Araujo, +244926670289, [email protected]

Location Countries


Location Countries


Administrative Informations



Organization ID


Responsible Party

Principal Investigator

Study Sponsor

EDGREM Investimentos


 University of Alabama at Birmingham

Study Sponsor

Moreno Araujo, Study Chair, EDGREN INVESTIMENTOS

Verification Date

November 2021