The Psychophysiological Effect of Simulated and Terrestrial Altitude

Learn more about:
Related Clinical Trial
Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude. Effect of Acetazolamide on Lung Water Content by Ultrasound in Lowlanders Older Than 40 Years at Altitude Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude Effect of Acetazolamide on Visuo-motor Learning in Lowlanders Older Than 40 Years at Altitude Effect of Acetazolamide on Maximal Exercise Performance in Lowlanders Older Than 40 Years at Altitude Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance Iron Status and Cardiopulmonary Physiology Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude. Effect of Acetazolamide on Postural Control in Lowlanders Older Than 40 Years at Altitude Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude The Psychophysiological Effect of Simulated and Terrestrial Altitude Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness Cardio-respiratory Responses During Hypoxic Exercise in Individuals Born Prematurely Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude AZ, MZ, and the Pulmonary System Response to Hypoxia Study of the Effects of Iron Levels on the Lungs at High Altitude Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort Three New Ideas to Protect Special Forces From the Stress of High Altitude Breathing Training to Improve Human Performance at High Altitude Oxidative Stress in Hypobaric Hypoxia Safety Evaluation of Aminophylline and Methazolamide Decompression Tables for Diving at Altitude Chronic Mountain Sickness, Systemic Vascular Function Evaluation of the Prevention and Treatment Effects of Chinese Medicine on High Altitude Illness Inhaled Budesonide for Altitude Illness Prevention Sickness Evaluation at Altitude With Acetazolamide at Relative Doses Prevention of Altitude Illness With Non-steroidal Anti-inflammatory Study (PAINS) Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE) Drug Combination on Exercise Performance at High Altitude Acclimatization Mechanisms During Ascent to 7500m Prevention of Acute Mountain Sickness by Intermittent Hypoxia Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID) Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent Training in Hypoxia to Prevent Acute Mountain Sickness Study of Compound Danshen Dripping Pills to Treat Acute Mountain Sickness Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy Controlled Hyperventilation as Prophylaxis for Acute Mountain Sickness Inhaled Budesonide and Acute Mountain Sickness Altitude Sickness Prevention and Efficacy of Comparative Treatments Alternative Treatments in Acute Mountain Sickness Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years Safety and Efficacy of T89 in Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)

Brief Title

The Psychophysiological Effect of Simulated and Terrestrial Altitude

Official Title

The Psychophysiological Effect of Simulated and Terrestrial Altitude

Brief Summary

      The aim of this study is to compare the psychophysiological effects of terrestrial altitude
      with a normobaric, hypoxic situation.
    

Detailed Description

      Research has consistently shown that exposure to extreme environments (such as high altitude
      stays) may affect cognitive function. For logistical reasons and to control the experimental
      set-ups, most of these examinations are carried out in the laboratory. By testing under such
      controlled conditions, researchers can remove any co-foundational factors and isolate the
      cause of stress, thereby better understanding the mechanisms by which impairment can occur.
      However, when people are exposed to such environments in the "real world" (such as altitude),
      they often experience a number of other additional stressors at the same time, which can also
      affect their performance. Surprisingly, however, little attention has been paid to the study
      of these additional stressors in combination.

      Although the oxygen content remains constant at various altitudes (20.93%), the air pressure
      decreases exponentially as the altitude increases. As a result, the oxygen partial pressure
      in arterial blood and tissue is reduced (hypoxia), leading to a deterioration in both
      physical and cognitive performance. Hypoxic conditions also alter the perception of pain,
      which may be particularly relevant for patients suffering from hypoxic conditions. According
      to the authors' knowledge, there is limited literature investigating and comparing simulated
      and real psychophysiological responses.
    


Study Type

Interventional


Primary Outcome

Perfusion of the skin microcirculation

Secondary Outcome

 Thermal comfort and sensation

Condition

Hypoxia

Intervention

Terrestrial altitude

Study Arms / Comparison Groups

 Simulated altitude
Description:  The participants are exposed to simulated altitude in a normobaric situation.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Behavioral

Estimated Enrollment

23

Start Date

October 1, 2019

Completion Date

December 2020

Primary Completion Date

July 2020

Eligibility Criteria

        Inclusion Criteria:

          -  Healthy, adults aged 18 to 50 years

          -  No cardiovascular disease and / or surgery

          -  no surgery on the cardiovascular system.

          -  No current injuries and / or pain

          -  Regular and adequate sleep

          -  No terrestrial altitude of 1000 m exceeded last month (including flights)

          -  No form of hypoxia exposed last month

        Exclusion Criteria:

          -  Age over 50 years

          -  current injuries of any kind and / or pain

          -  Acute and / or chronic pain conditions Known general diseases (e.g., diabetes
             mellitus)

          -  fear of hypoxia

          -  fear of heights or sensitivity to terrestrial altitude

          -  Regular use of medicines (also bought by yourself), except for contraceptives

          -  Cardiovascular diseases or abnormalities

          -  Anomalies of the blood analysis or ECG

          -  Psychological disorders

          -  pregnancy / lactation
      

Gender

All

Ages

18 Years - 50 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

, +41 81 3000 175, [email protected]

Location Countries

Switzerland

Location Countries

Switzerland

Administrative Informations


NCT ID

NCT04075565

Organization ID

2019-00504


Responsible Party

Sponsor

Study Sponsor

University of Applied Sciences and Arts of Southern Switzerland

Collaborators

 University of Portsmouth

Study Sponsor

, , 


Verification Date

August 2019