The Psychophysiological Effect of Simulated and Terrestrial Altitude

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Brief Title

The Psychophysiological Effect of Simulated and Terrestrial Altitude

Official Title

The Psychophysiological Effect of Simulated and Terrestrial Altitude

Brief Summary

      The aim of this study is to compare the psychophysiological effects of terrestrial altitude
      with a normobaric, hypoxic situation.

Detailed Description

      Research has consistently shown that exposure to extreme environments (such as high altitude
      stays) may affect cognitive function. For logistical reasons and to control the experimental
      set-ups, most of these examinations are carried out in the laboratory. By testing under such
      controlled conditions, researchers can remove any co-foundational factors and isolate the
      cause of stress, thereby better understanding the mechanisms by which impairment can occur.
      However, when people are exposed to such environments in the "real world" (such as altitude),
      they often experience a number of other additional stressors at the same time, which can also
      affect their performance. Surprisingly, however, little attention has been paid to the study
      of these additional stressors in combination.

      Although the oxygen content remains constant at various altitudes (20.93%), the air pressure
      decreases exponentially as the altitude increases. As a result, the oxygen partial pressure
      in arterial blood and tissue is reduced (hypoxia), leading to a deterioration in both
      physical and cognitive performance. Hypoxic conditions also alter the perception of pain,
      which may be particularly relevant for patients suffering from hypoxic conditions. According
      to the authors' knowledge, there is limited literature investigating and comparing simulated
      and real psychophysiological responses.

Study Type

Interventional

Primary Outcome

Perfusion of the skin microcirculation

Secondary Outcome

 Thermal comfort and sensation

Condition

Hypoxia

Intervention

Terrestrial altitude

Study Arms / Comparison Groups

 Simulated altitude
Description:  The participants are exposed to simulated altitude in a normobaric situation.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Behavioral

Estimated Enrollment

23

Start Date

October 1, 2019

Completion Date

September 2022

Primary Completion Date

September 2021

Eligibility Criteria

        Inclusion Criteria:

          -  Healthy, adults aged 18 to 50 years

          -  No cardiovascular disease and / or surgery

          -  no surgery on the cardiovascular system.

          -  No current injuries and / or pain

          -  Regular and adequate sleep

          -  No terrestrial altitude of 1000 m exceeded last month (including flights)

          -  No form of hypoxia exposed last month

        Exclusion Criteria:

          -  Age over 50 years

          -  current injuries of any kind and / or pain

          -  Acute and / or chronic pain conditions Known general diseases (e.g., diabetes
             mellitus)

          -  fear of hypoxia

          -  fear of heights or sensitivity to terrestrial altitude

          -  Regular use of medicines (also bought by yourself), except for contraceptives

          -  Cardiovascular diseases or abnormalities

          -  Anomalies of the blood analysis or ECG

          -  Psychological disorders

          -  pregnancy / lactation

Gender

All

Ages

18 Years - 50 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

, +41 81 3000 175, [email protected]

Location Countries

Switzerland

Location Countries

Switzerland

Administrative Informations

NCT ID

NCT04075565

Organization ID

2019-00504

Responsible Party

Sponsor

Study Sponsor

University of Applied Sciences and Arts of Southern Switzerland

Collaborators

 University of Portsmouth

Study Sponsor

, ,

Verification Date

May 2021