Oxidative Stress in Hypobaric Hypoxia

Learn more about:
Related Clinical Trial
Colorado-Oregon Altitude Study The Effects of Intermittent Hypoxia on Acute Hypoxic Injury Effect of Isocaloric Ketogenic Diet on Physical Performance at High Altitude The Pre-acclimatization Augmented Extreme Altitude Expedition Effect of Altitude on Iron Absorption in Iron Depleted Women Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide Safety and Efficacy of T89 in the Prevention and Treatment of Adults With Acute Mountain Sickness (AMS) Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD HIGH Altitude CArdiovascular REsearch Latin America Population Study Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude. Effect of Acetazolamide on Lung Water Content by Ultrasound in Lowlanders Older Than 40 Years at Altitude Effect of Acetazolamide on Right Heart Function During Exercise in Lowlanders Older Than 40 Years at Altitude Effect of Acetazolamide on Visuo-motor Learning in Lowlanders Older Than 40 Years at Altitude Effect of Acetazolamide on Maximal Exercise Performance in Lowlanders Older Than 40 Years at Altitude Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance Iron Status and Cardiopulmonary Physiology Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders Older Than 40 Years at Altitude. Effect of Acetazolamide on Postural Control in Lowlanders Older Than 40 Years at Altitude Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude The Psychophysiological Effect of Simulated and Terrestrial Altitude Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness Cardio-respiratory Responses During Hypoxic Exercise in Individuals Born Prematurely Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude AZ, MZ, and the Pulmonary System Response to Hypoxia Study of the Effects of Iron Levels on the Lungs at High Altitude Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort Three New Ideas to Protect Special Forces From the Stress of High Altitude Breathing Training to Improve Human Performance at High Altitude Oxidative Stress in Hypobaric Hypoxia Safety Evaluation of Aminophylline and Methazolamide Decompression Tables for Diving at Altitude Chronic Mountain Sickness, Systemic Vascular Function Evaluation of the Prevention and Treatment Effects of Chinese Medicine on High Altitude Illness Inhaled Budesonide for Altitude Illness Prevention Sickness Evaluation at Altitude With Acetazolamide at Relative Doses Prevention of Altitude Illness With Non-steroidal Anti-inflammatory Study (PAINS) Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE) Drug Combination on Exercise Performance at High Altitude Acclimatization Mechanisms During Ascent to 7500m Prevention of Acute Mountain Sickness by Intermittent Hypoxia Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID) Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent Training in Hypoxia to Prevent Acute Mountain Sickness Study of Compound Danshen Dripping Pills to Treat Acute Mountain Sickness Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy Controlled Hyperventilation as Prophylaxis for Acute Mountain Sickness Inhaled Budesonide and Acute Mountain Sickness Altitude Sickness Prevention and Efficacy of Comparative Treatments Alternative Treatments in Acute Mountain Sickness Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years Safety and Efficacy of T89 in Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)

Brief Title

Oxidative Stress in Hypobaric Hypoxia

Official Title

Oxidative Stress in Hypobaric Hypoxia and Influence on Vessel-tone Modifying Mediators

Brief Summary

      The trial investigates changes in metabolism during high altitude expedition up to 6865m. A
      mass-spectrometry based platform is used to detect different oxidative stress related
      metabolites. Symptoms of acute mountain sickness are evaluated and correlated with laboratory
      parameters.
    

Detailed Description

      Background

      Altitude related illness, which include acute mountain sickness (AMS), high altitude
      pulmonary edema (HAPE) and high altitude cerebral edema (HACE), is common in subjects exposed
      to high altitude during professional or leisure time activities. There are independent risk
      factors such as: individual susceptibility and rate of ascent. HAPE is a potentially
      life-threatening complication of high altitude stay, mostly occuring within the first 2-5
      days of exposure. Although there is a controversial discussion, excessive hypoxic pulmonary
      vasoconstriction is thought to be the main trigger for developing HAPE. Beside the
      controversial discussion if hypobaric hypoxia leads to oxidative stress it is not known
      whether oxidative stress contributes to AMS or HAPE.

      Objective

      The investigators hypothesize that reactive oxygen species are generated during high altitude
      stay and contribute to the development of acute mountain sickness. Furthermore they would
      like to describe other changes in metabolic pathways possibly contributing to vessel tone
      dysregulation.

      Methods

      36 healthy volunteers will examined during an high altitude medical research expedition to
      Mount Muztagh ata (7549m) in Western China. Acute mountain sickness scores and clinical
      parameters will be assessed. Metabolomics analysis of more than 390 parameters, using a mass
      spectrometry-based targeted metabolomic platform, is used to detect systemic oxidative stress
      and functional impairment of enzymes that require oxidation-sensitive co-factors. Furthermore
      routine laboratory test will be done, for example CRP, creatinine and interleukines
    


Study Type

Interventional


Primary Outcome

Number of volunteers with acute mountain sickness

Secondary Outcome

 Change from baseline in oxygen saturation in blood

Condition

Hypobaric Hypoxia

Intervention

Hypoxic exposure


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

36

Start Date

March 2005

Completion Date

February 2010

Primary Completion Date

December 2005

Eligibility Criteria

        Inclusion Criteria:

          -  healthy

          -  physical fit

          -  mountaineering experience

          -  18-70 years

        Exclusion Criteria

          -  any type of disease

          -  regular intake of medicaments

          -  history of high altitude pulmonary edema

          -  severe acute mountain sickness below an altitude of 3500m

          -  any history of high altitude cerebral edema
      

Gender

All

Ages

18 Years - 70 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Andreas Huber, Prof. Dr. med., , 

Location Countries

Switzerland

Location Countries

Switzerland

Administrative Informations


NCT ID

NCT01436383

Organization ID

KEK 1189

Secondary IDs

SNSF 3200B0-108300


Study Sponsor

University Hospital Inselspital, Berne

Collaborators

 Swiss National Science Foundation

Study Sponsor

Andreas Huber, Prof. Dr. med., Study Chair, Center of Laboratory Medicine, Cantonal Hospital Aarau, 5001 Aarau


Verification Date

September 2011