Breathing Training to Improve Human Performance at High Altitude

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Brief Title

Breathing Training to Improve Human Performance at High Altitude

Official Title

Breathing Training to Improve Human Performance at High Altitude

Brief Summary

      Individuals traveling to altitudes above 8,000 feet may suffer from impaired exercise and
      cognitive performance, and acute mountain sickness (AMS). Decreased barometric pressure,
      which leads to low blood oxygen levels, is the primary cause of these disorders. Symptoms of
      AMS are characterized by headache, nausea, vomiting, dizziness, fatigue, and difficulty
      sleeping. The goal of this research is to identify whether Respiratory Muscle Training will
      improve physical and cognitive performance, and reduce the symptoms of AMS, at simulated high
      altitude.

Study Type

Interventional

Primary Outcome

Change in exercise performance during acute simulated high-altitude exposure as measured by a peak oxygen uptake test and time to complete a 720kJ (40km) time trial on a Velotron cycle ergometer.

Condition

Mountain Sickness Acute

Intervention

Respiratory Muscle Training

Study Arms / Comparison Groups

 Respiratory Muscle Training
Description:

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Device

Estimated Enrollment

28

Start Date

August 9, 2018

Completion Date

January 15, 2020

Primary Completion Date

January 15, 2020

Eligibility Criteria

        Inclusion Criteria:

          -  Healthy

          -  Men, ages 18-45 who are able to achieve at least 3.5 watts/kg of body weight during
             the peak oxygen uptake test

        Exclusion Criteria:

          -  Less than 18 years old

          -  Greater than 45 years old

          -  Have a body mass index greater than or equal to 30

          -  Have been recent smokers (tobacco or e-cigarettes)

          -  Current recreational or medical marijuana users

          -  Currently taking any medication (over-the-counter or prescription) or herbal
             supplements

          -  Participants who are unable to tolerate drinking only two, 6-ounce caffeinated
             beverages per day of the study

          -  Participants who are legally blind

          -  Participants who have been to altitudes above Denver (1609m or 5280ft), including air
             travel, in the 3 weeks prior to the start of the study or with plans to do so during
             the study

          -  Participants who have suffered a significant head injury, have anemia or sickle cell
             trait or disease, have active peptic ulcer disease, diabetes, hypertension, heart
             disease, HIV/AIDS, glaucoma, kidney disease, liver disease/cirrhosis, adrenal gland
             failure, hyponatremia/hypokalemia, tuberculosis

          -  Participants who have a current herpes infection or any other current type of viral or
             bacterial infection

          -  Participants with seizure disorders or history of migraines

Gender

Male

Ages

18 Years - 45 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Robert Roach, PhD, ,

Location Countries

United States

Location Countries

United States

Administrative Informations

NCT ID

NCT03530163

Organization ID

18-0464

Responsible Party

Sponsor

Study Sponsor

University of Colorado, Denver

Collaborators

 United States Department of Defense

Study Sponsor

Robert Roach, PhD, Principal Investigator, Director, Altitude Research Center

Verification Date

April 2022