The Effect of Therapy With Bevacizumab in Chronic Central Serous Chorioretinopathy

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Brief Title

The Effect of Therapy With Bevacizumab in Chronic Central Serous Chorioretinopathy

Official Title

Intraocular Concentrations of Growth Factors and Cytokines in Chronic Central Serous Chorioretinopathy And the Effect of Therapy With Bevacizumab

Brief Summary

      The pathophysiology of central serous chorioretinopathy remains controversial. traditional
      treatment is laser photocoagulation or photodynamic therapy.Recently Bevacizumab (Avastin,
      Genetech),an antibody to vascular endothelial growth factor (VEGF),has known antipermeability
      properties and therefore may theoretically reverse the changes seen in central serous
      chorioretinopathy. The aim of this study is To investigate concentrations of growth factors
      and inflammatory cytokines and to report the effect of therapy with bevacizumab in eyes with
      central serous chorioretinopathy
    



Study Type

Interventional


Primary Outcome

Concentrations of growth factors and inflammatory cytokines in Aqueous humor

Secondary Outcome

 Central macular thickness at optical coherence tomography

Condition

Central Serous Chorioretinopathy

Intervention

intravitreal injection with anterior paracentesis


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Procedure

Estimated Enrollment

10

Start Date

March 2009

Completion Date

March 2010

Primary Completion Date

March 2010

Eligibility Criteria

        Inclusion Criteria:

          -  Patients with a diagnosis of central serous chorioretinopathy

          -  Idiopathic neurosensory retinal elevation demonstrated by optical coherent tomography

          -  Presence of focal leaks at the level of the RPE on fluorescein angiography

        Exclusion Criteria:

          -  Known side effects of systemic bevacizumab administration

          -  Have a significant cardiovascular or thromboembolic history or were pregnant
      

Gender

All

Ages

30 Years - 60 Years

Accepts Healthy Volunteers

No

Contacts

, , 



Administrative Informations


NCT ID

NCT00864773

Organization ID

2009-3-16



Study Sponsor

Hallym University Medical Center


Study Sponsor

, , 


Verification Date

March 2009