Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

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Brief Title

Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

Official Title

Comparison of Multifocal Electroretinogram Assessment Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

Brief Summary

      This study is a comparison of multifocal electroretinogram assessment between the laser
      treatment group and the photodynamic therapy group in chronic central serous
      chorioretinopathy.
    

Detailed Description

      1. Laser Group: extrafoveal focal leakage on FAG

        2. PDT Group: no definite focal leak on FAG subfoveal or juxtafoveal focal leakage on FAG,
           or serous retinal pigmentary epithelial detachment involving foveal center

      Inclusion criteria

        1. Chronic serous chorioretinopathy (over 3 months) when subretinal fluid persisted in the
           subfoveal region demonstrated by clinical examination and OCT

        2. Ability to maintain steady fixation for mfERG

        3. Presence of abnormal dilated choroidal vasculature in ICGA

        4. Symptom duration over 3 months

      Exclusion criteria

        1. previous PDT or laser treatment history

        2. evidence of Choriinal neovascularization in FAG

        3. other chorioretinal disorders that can cause macular exudation such as age-related
           macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases,
           retinal vasculopathies, and hereditary dystrophies

      follow-up Visit

      1)baseline 2)1month 3)3months 4)6 months

      each visit: multifocal electroretinogram, visual acuity, optical coference timography should
      be measured.
    


Study Type

Observational


Primary Outcome

Multifocal Electroretinogram Amplitudes

Secondary Outcome

 Best Corrected Visual Acuity

Condition

Central Serous Chorioretinopathy


Study Arms / Comparison Groups

 Photodynamic therapy (PDT)
Description:  

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

24

Start Date

March 2008

Completion Date

October 2008

Primary Completion Date

October 2008

Eligibility Criteria

        Inclusion Criteria:

          1. CSC (over 3 months) when subretinal fluid persisted in the subfoveal region
             demonstrated by clinical examination and OCT

          2. Ability to maintain steady fixation for mfERG

          3. Presence of abnormal dilated choroidal vasculature in ICGA

          4. Symptom duration over 3 months

        Exclusion Criteria:

          1. Previous PDT or laser treatment history

          2. Evidence of CNV in FAG

          3. Other chorioretinal disorders that can cause macular exudation such as age-related
             macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory
             diseases, retinal vasculopathies, and hereditary dystrophies
      

Gender

All

Ages

20 Years - 80 Years

Accepts Healthy Volunteers

No

Contacts

Se Woong Kang, MD, , 

Location Countries

Korea, Republic of

Location Countries

Korea, Republic of

Administrative Informations


NCT ID

NCT00803517

Organization ID

2008-05-030



Study Sponsor

Samsung Medical Center


Study Sponsor

Se Woong Kang, MD, Study Chair, Samsung Medical Center


Verification Date

February 2009