Effect of Helicobacter Pylori Treatment on Idiopathic Central Serous Chorioretinopathy (ICSCR)

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Brief Title

Effect of Helicobacter Pylori Treatment on Idiopathic Central Serous Chorioretinopathy (ICSCR)

Official Title

Effect of Helicobacter Pylori Treatment on Remission of Idiopathic Central Serous Chorioretinopathy (ICSCR)

Brief Summary

      Etiology of ICSCR is not known however recent studies regard the role of immunologic and
      infectious processes in the pathogenesis of ICSCR.one of these hypothesis is the role of
      helicobacter pylori in the pathogenesis of ICSCR so perhaps treatment of h pylori have
      positive effect on the remission of ICSCR.
    

Detailed Description

      we will choose 50 cases of patients with ICSCR who are infected with h.pylori.25 cases will
      receive anti h.pylori regiment and 25 cases as controls will receive no medication.then we
      will compare the time of submacular fluid resorption and macular thickness and visual acuity
      among these two groups.
    

Study Phase

Phase 1/Phase 2

Study Type

Interventional


Primary Outcome

Subretinal fluid level

Secondary Outcome

 time of sub macular fluid absorption

Condition

Central Serous Chorioretinopathy

Intervention

omeprazole, Amoxicillin, metronidazole

Study Arms / Comparison Groups

 1
Description:  Oral Amoxicillin Capsule Metronidazole Tablet Omeprazole Capsule

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

50

Start Date

March 2008

Completion Date

January 2009

Primary Completion Date

October 2008

Eligibility Criteria

        Inclusion Criteria:

          -  the persons who are infected with helicobacter pylori and have ICSCR

        Exclusion Criteria:

          -  history of previous eye surgery ,to have indication of laser therapy,corticosteroid
             therapy,pregnancy,
      

Gender

All

Ages

28 Years - 40 Years

Accepts Healthy Volunteers

No

Contacts

Alireza Javadzadeh, , 

Location Countries

Iran, Islamic Republic of

Location Countries

Iran, Islamic Republic of

Administrative Informations


NCT ID

NCT00817245

Organization ID

86-47



Study Sponsor

Tabriz University


Study Sponsor

Alireza Javadzadeh, Study Chair, Alireza Javadzadeh


Verification Date

January 2009