Micropulse Diode Laser Treatment for Chronic Central Serous Chorioretinopathy

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Central serous chorioretinopathy
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Brief Title

Micropulse Diode Laser Treatment for Chronic Central Serous Chorioretinopathy

Official Title

Micropulse Diode Laser Treatment for Chronic Central Serous Chorioretinopathy: Evaluation by Fundus Autofluorescence and Spectral Domain Optical Coherence Tomography

Brief Summary

      The aim of this study was to evaluate safety and therapeutic response to micropulse diode
      810nm laser treatment in patients with chronic central serous chorioretinopathy.

Detailed Description

      Most of the cases of central serous chorioretinopathy (CSC) recur spontaneously within three
      months of disease. After 3 months without resolution of acute CSC or in chronic CSC,
      continuous wave laser photocoagulation or photodynamic therapy should be considered. Direct
      threshold continuous photocoagulation treatment can shorten the duration of the serous
      detachment, but it is not appropriate for juxtafoveal or subfoveal leakage point.Subvisible
      photocoagulation potentially localizes and decreases chorioretinal thermic burn. Subthreshold
      diode micropulse (SDM) laser using a 810nm diode laser may spare the damage to the neural
      retina by raising the temperature of the RPE to just below the protein-denaturation threshold
      so that the thermal wave that reaches the neural retina is insufficient to cause neither
      damage nor clinically visible end-point. This therapeutic laser modality offers the
      possibility to minimize the iatrogenic retinal lesion.

Study Type

Interventional

Primary Outcome

Best corrected visual acuity

Secondary Outcome

 Macular subretinal fluid

Condition

Central Serous Chorioretinopathy

Intervention

Subthreshold diode micropulse laser

Study Arms / Comparison Groups

 Subthreshold diode micropulse laser
Description:  Subthreshold diode micropulse laser in patients with chronic central serous chorioretinopathy

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Procedure

Estimated Enrollment

15

Start Date

November 2008

Completion Date

June 2010

Primary Completion Date

December 2009

Eligibility Criteria

        Inclusion Criteria:

          -  Chronic active central serous chorioretinopathy lasting more than 6 months

          -  Leakage at fluorescein angiogram

        Exclusion Criteria:

          -  Opacities of the clear refractive media of the eye

          -  Any intraocular surgery within the 6 months prior to study entry

          -  Prior vitrectomy

Gender

All

Ages

18 Years - 70 Years

Accepts Healthy Volunteers

No

Contacts

Fernanda P Magalhaes, MD, ,

Location Countries

Brazil

Location Countries

Brazil

Administrative Informations

NCT ID

NCT01327170

Organization ID

SDMCCSC-FM

Study Sponsor

Federal University of São Paulo

Study Sponsor

Fernanda P Magalhaes, MD, Principal Investigator, Federal University of São Paulo

Verification Date

March 2011