Brinzolamide for the Treatment of Chronic Central Serous Chorioretinopathy

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Brief Title

Brinzolamide for the Treatment of Chronic Central Serous Chorioretinopathy

Official Title

Brinzolamide for the Treatment of Chronic Central Serous Chorioretinopathy

Brief Summary

      Examine the efficacy of brinzolamide for the treatment of central serous chorioretinopathy
    

Detailed Description

      Brinzolamide is a carbonic anhydrase inhibitor. Previously, carbonic anhydrase inhibitors
      have been shown to be effective for the treatment of macular edema when administered orally,
      also for central serous chorioretinopathy. However, this treatment carries the risk of severe
      side effects.

      The goal of this study is to examine the efficacy of the topical form of treatment of
      carbonic anhydrase inhibitors in patients with chronic, non-resolving, central serous
      chorioretinopathy.
    

Study Phase

Phase 2

Study Type

Interventional


Primary Outcome

Change in subretinal fluid (microns)

Secondary Outcome

 Change in ETDRS visual acuity (number of letters)

Condition

Central Serous Chorioretinopathy

Intervention

Brinzolamide Ophthalmic

Study Arms / Comparison Groups

 Topical brinzolamide
Description:  Brinzolamide ophthalmic, given bd for 3 months

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

35

Start Date

June 1, 2018

Completion Date

April 1, 2019

Primary Completion Date

January 1, 2019

Eligibility Criteria

        Inclusion Criteria:

          -  Central serous chorioretinopathy (CSC) affecting the fovea, non-resolving after 4
             months of follow-up

          -  Optical coherence tomography (OCT) shows foveal subretinal fluid

          -  Fluorescein angiography and indocyanine green confirm the diagnosis

        Exclusion Criteria:

          -  Any other ophthalmic condition that may lead to subretinal fluid

          -  Choroidal neovascularization

          -  Myopia > -6D

          -  Previous treatment for CSC in the past 6 months

          -  Known allergy to fluorescein or indocyanin green

          -  Known allergy for brinzolamide

          -  Pregnancy, breast feeding
      

Gender

All

Ages

18 Years - 60 Years

Accepts Healthy Volunteers

No

Contacts

Dinah Zur, +97236973408, [email protected]

Location Countries

Argentina

Location Countries

Argentina

Administrative Informations


NCT ID

NCT03542006

Organization ID

0647-17


Responsible Party

Principal Investigator

Study Sponsor

Tel-Aviv Sourasky Medical Center


Study Sponsor

Dinah Zur, Principal Investigator, Tel-Aviv Sourasky Medical Center


Verification Date

May 2018