Somatostatin Analogues in the Treatment of Relapsing GH Pituitary Adenomas After Surgery

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Brief Title

Somatostatin Analogues in the Treatment of Relapsing GH Pituitary Adenomas After Surgery

Official Title

Maintenance of Remission After Discontinuation of Somatostatin Analogues in the Treatment of Relapsing GH Pituitary Adenomas After Surgery

Brief Summary

      At present there are no recommendations regarding the possibility of discontinuing treatment
      in cases of recurrent acromegaly with good hormonal control. Discontinuation of treatment is
      therefore most often decided by the practitioner, on the basis of his experience and
      knowledge of the patient, the long-term course with somatostatin analogues being very little
      described.

      Thus, although hormonal control is achieved in a majority of cases under medical treatment,
      we do not know if it is possible to stop treatment and in this case how the pathology
      evolves. It would appear that approximately 40% of patients defined as very good responders
      to somatostatin analogues may gradually space their injections.

Study Type

Observational

Primary Outcome

Study of the clinical and biological evolution, after discontinuation of treatment with somatostatin analogues, of acromegalic patients with recurrence after surgery.

Condition

Acromegaly

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

100

Start Date

October 1, 2021

Completion Date

March 20, 2023

Primary Completion Date

March 2023

Eligibility Criteria

        Inclusion criteria:

          -  Major subject (≥18 years old)

          -  Having been seen at least once in consultation in the Internal Medicine, Endocrinology
             and Nutrition department of Hautepierre Hospital

          -  Subject operated for a pituitary adenoma at the HUS between 01/01/2000 to 09/01/2021

          -  In whom biological confirmation of recurrence has been demonstrated

          -  Patient not having expressed his opposition, after information, to the reuse of his
             data for scientific research purposes.

        Exclusion criteria:

          -  Subject having expressed opposition to participating in the study

          -  Treatment pre and / or post surgery by radiotherapy

          -  No recurrence

          -  No treatment with a somatostatin analogue for recurrence

          -  Subject under guardianship, curatorship or safeguard of justice

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Philippe BALTZINGER, MD, 33 3 88 12 75 82, [email protected]

Location Countries

France

Location Countries

France

Administrative Informations

NCT ID

NCT05149495

Organization ID

8409

Responsible Party

Sponsor

Study Sponsor

University Hospital, Strasbourg, France

Study Sponsor

Philippe BALTZINGER, MD, Principal Investigator, Service Médecine Interne, Endocrinologie et Nutrition - Hôpitaux Universitaires de Strasbourg

Verification Date

November 2021