Micromegaly and Discrepancy Between Growth Hormone and IGF1 at the Diagnosis and Follow-up of Acromegalic Patients

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Brief Title

Micromegaly and Discrepancy Between Growth Hormone and IGF1 at the Diagnosis and Follow-up of Acromegalic Patients

Official Title

Micromegaly and Discrepancy Between Growth Hormone and IGF1 at the Diagnosis and Follow-up of Acromegalic Patients : What About Their Consequences ?

Brief Summary

      The diagnosis and the follow-up of acromegalic patients are based on the mesurement of Growth
      hormone (GH) and IGF1 rates. However, the literature described some cases of patient for whom
      the investigators observed a discrepancy between GH and IGF1 rates. Since the acromegaly is a
      rare disease and this phenomenon concerns about 30% of these patients, there is a lack of
      investigations about consequences that this discordance may induces. In this study, the
      investigators aimed at assessing if patients with discordance between GH and IGF1 rates
      present a different risk of recurrence and complications related to acromegaly, from patients
      with concordant results.

Study Type

Observational

Primary Outcome

Occurrence of complications and/or recidivism related to acromegaly

Secondary Outcome

 Disease's specificity

Condition

Acromegaly

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment

250

Start Date

January 1, 2010

Completion Date

December 1, 2022

Primary Completion Date

April 1, 2022

Eligibility Criteria

        Inclusion criteria:

          -  Acromegaly followed up in one of the center (Montpellier, Nimes or Béziers hospital,
             independent endocrinologist) between 2010 and 2021

          -  Age over 18 years old

          -  Measurement of GH and IGF1 rates at the last visit control available

        Exclusion criteria:

          -  Lost to follow-up

          -  Status about complications related to acromegaly unknown

Gender

All

Ages

18 Years - 100 Years

Accepts Healthy Volunteers

No

Contacts

Isabelle RAINGEARD, 06.71.31.76.37, [email protected]

Location Countries

France

Location Countries

France

Administrative Informations

NCT ID

NCT04860037

Organization ID

RECHMPL21_0229

Responsible Party

Sponsor

Study Sponsor

University Hospital, Montpellier

Study Sponsor

Isabelle RAINGEARD, Principal Investigator, University Hospital, Montpellier

Verification Date

April 2021