Brief Title
Fractionated Stereotactic Radiotherapy in Patients With Acromegaly
Official Title
Fractionated Stereotactic Radiotherapy in Patients With Acromegaly. Single Centre Experience
Brief Summary
Hypothesis: Fractionated stereotactic radiotherapy is a safe therapy for treatment of patients with acromegaly in terms of both tumour control and biochemical remission
Detailed Description
An audit was done on 34 patients with acromegaly (consecutive cohorte) treated with fractionated stereotactic radiotherapy in Rigshospitalet/National University Hospital, Copenhagen, Denmark. All patients had MR control regularly to monitor tunour control, and biochemical control assessed by growth hormone measurements during an oral glucose tolerance test. Furthermore all other pituitary axes were tested for sufficiency and concomitant medication likewise registered. The 7 year interim analysis demonstrated an acceptable tumour control and biochemical remission profile, and most patient had subsequent withdrawal of somatostatin analogue- and growth hormone receptor antagonis therapy. The observational study will continue with a new update in approx 2 years
Study Type
Observational
Primary Outcome
Tumour control by pituitary MRI
Secondary Outcome
biochemical remission
Condition
Acromegaly
Intervention
fractionated stereotactic radiotherapy
Study Arms / Comparison Groups
Fractionated stereotactic radiotherapy
Description: patients with active acromegaly
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Radiation
Estimated Enrollment
34
Start Date
January 2002
Completion Date
January 2008
Primary Completion Date
January 2008
Eligibility Criteria
Inclusion Criteria: adults active acromegaly pituitary tumour on MRI biochemical activity - Exclusion Criteria: pregnancy no visible tumour on MRI -
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
, ,
Location Countries
Denmark
Location Countries
Denmark
Administrative Informations
NCT ID
NCT00934271
Organization ID
FSRT-SR-UFR
Responsible Party
Principal Investigator
Study Sponsor
Rigshospitalet, Denmark
Study Sponsor
, ,
Verification Date
October 2014