Brief Title
Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients
Official Title
Olfactory Function and Olfactory Bulb Volume in Acromegaly Patients
Brief Summary
A prospective, controlled, single blinded study was planned. 20 patients with Acromegaly (Acromegaly Group) and 20 healthy subjects (Control Group) were planned to include in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. Olfactory bulb(OB) volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.
Detailed Description
Acromegaly patients were assessed at the Endocrinology Department for their clinical symptoms, and the nasal examination and olfactory evaluation were done at the Department of Otorhinolaryngology. OB volume was evaluated by a single blinded radiologist. Control group patients that had similar demographical characteristics with the Acromegaly Group were recruited in the study. The CCCRC test is composed of n-butanol odor threshold test and odor identification test. Olfactory tests were scored out of 7 (0: worst, 7: best olfaction) and mean score was calculated as the total CCCRC test score. OB measurements were done individually on the right and left olfactory bulbs and the mean OB volume was calculated in cubic millimeters.
Study Type
Interventional
Primary Outcome
Olfactory bulb (OB) volume
Condition
Acromegaly
Intervention
OB volume
Study Arms / Comparison Groups
Acromegaly group
Description: CCCRC test and OB volume results
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
40
Start Date
August 15, 2018
Completion Date
January 30, 2020
Primary Completion Date
December 10, 2019
Eligibility Criteria
Inclusion Criteria: - Acromegaly diagnosis - Healthy subjects that had no nasal problems Exclusion Criteria: - Previous nasal surgery - Acute respiratory tract infection - Nasal polyposis - Nasal pathologies that causes nasal obstruction
Gender
All
Ages
18 Years - 80 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Nazan Degirmenci, ,
Location Countries
Turkey
Location Countries
Turkey
Administrative Informations
NCT ID
NCT04138537
Organization ID
20/10.11.10.2017
Responsible Party
Sponsor
Study Sponsor
Bezmialem Vakif University
Study Sponsor
Nazan Degirmenci, Principal Investigator, Bezmialem Vakif University
Verification Date
March 2020