Brief Title
Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly
Official Title
Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly
Brief Summary
This study investigates fat distribution in people with acromegaly. The investigator is also investigating the change of fat distribution before and after treatment of acromegaly. The investigator will compare the results of people with acromegaly to the results of healthy volunteers.
Study Type
Observational
Primary Outcome
Change in Liver Fat
Condition
Acromegaly
Study Arms / Comparison Groups
Active Acromegaly
Description: All study subjects with acromegaly will be studied twice - once during the active stage of their disease (pre-treatment) and a second time: 3 months after treatment of acromegaly. Controls will be studied at one time point.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
40
Start Date
April 2013
Completion Date
March 30, 2016
Primary Completion Date
March 30, 2016
Eligibility Criteria
Inclusion Criteria: - Ages 18 - 75 yr (both groups) - Study subjects with active acromegaly - Healthy controls Exclusion Criteria: - Serum creatinine or alanine aminotransferase (ALT) > 2 times the upper limit of normal, metastatic cancer. - Controls will be receiving no medications and have no chronic diseases, including cancer, hypertension or diabetes mellitus. - Contraindications to MRI imaging (both groups) like those with certain metal implants, surgical clips or pacemakers. - Pregnant women
Gender
All
Ages
18 Years - 75 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Karen Miller, MD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT01819883
Organization ID
2012P002517
Responsible Party
Principal Investigator
Study Sponsor
Massachusetts General Hospital
Collaborators
Ipsen
Study Sponsor
Karen Miller, MD, Principal Investigator, Massachusetts General Hospital
Verification Date
June 2018