Oral Manifestations of Aplastic Anemia

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Brief Title

Oral Manifestations of Aplastic Anemia

Official Title

Oral Manifestations of Aplastic Anemia

Brief Summary

      The purposes of this study are threefold: 1) to evaluate the prevalence and risks of oral
      complications in patients with aplastic anemia; 2) to evaluate if oral problems in these
      patients can predict their response to treatment; and 3) to review complications of dental
      treatment in these patients in order to establish treatment guidelines.

      This study will be performed through a review of medical charts of 79 patients with aplastic
      anemia and 67 patients with schizophrenia who were treated at the National Institutes of
      Health Dental Clinic between 1993 and 1999. The schizophrenia patients will serve as a
      control population.

      Demographic, clinical and radiographic information will be collected for all patients.
      Additional data collected only for aplastic anemia patients will include medical therapy,
      disease duration, blood cell counts, oral problems that developed during treatment and
      treatment response.
    

Detailed Description

      The prevalence, risk factors and significance of oral manifestations in aplastic anemia have
      not been well characterized. Thus, in the present study, through a retrospective chart
      review, we document the prevalence of oral complications in AA patients and the risks for
      oral manifestations in a case-control study. Schizophrenic patients represent controls.
      Information includes the following; demographic, clinical and radiographic information for
      cases and controls. Additional data collection for only AA patients includes prior medical
      therapy, CBC and differential, disease duration, new oral manifestations during AA treatment
      and medical treatment response. We determine if systemic clinical features of AA predict oral
      manifestations, and if oral manifestations predict treatment outcomes for AA patients.
      Finally complications following dental treatment are compiled and reviewed to establish
      initial treatment guidelines for these patients.
    


Study Type

Observational




Condition

Aplastic Anemia



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

146

Start Date

April 2000

Completion Date

April 2002


Eligibility Criteria

        INCLUSION CRITERIA:

        Cases: All aplastic anemia patients evaluated at the NIH dental clinic for consultation
        between 1993-1999.

        Controls: All schizophrenic patients evaluated at the NIH dental clinic for consultation
        between 1993-1999.

        EXCLUSION CRITERIA:

        Patients without the diagnosis of aplastic anemia for cases or schizophrenia for the
        controls.
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT00006300

Organization ID

000113

Secondary IDs

00-D-0113


Study Sponsor

National Institute of Dental and Craniofacial Research (NIDCR)


Study Sponsor

, , 


Verification Date

April 2002