Brief Title
Aplastic Anemia Epidemiology: Incidence and Case-control
Brief Summary
To conduct incidence and case-control studies of aplastic anemia in metropolitan Bangkok,
Thailand
Detailed Description
BACKGROUND:
Aplastic anemia, a form of bone marrow failure, is a disease of largely unknown cause, except
for the rare situations involving high doses of radiation. Many agents have been mentioned in
case reports to be associated with the development of aplastic anemia and include drugs,
chemicals, pesticides, radiation, and viral infection. Of these, chloramphenicol,
phenylbutazone, and insecticides are most frequently reported. In the United States and other
developed countries the disease prevalence is so low that too few cases occur to make an
epidemiological study in a single city logistically feasible. The Bangkok hospitalization
rate for aplastic anemia was sufficient to conduct a case-control study. Also, a study
conducted in this locale provided information on drugs and chemicals not commonly used in
developed countries.
DESIGN NARRATIVE:
All aplastic anemia cases in metropolitan Bangkok were located and verified in the forty
hospitals that agreed to participate in the study. Incidence rates were calculated by age
group and sex. In the case-control study, interviews were used to obtain comprehensive
histories of drug, chemical, pesticide, radiation, viral infections, and other exposures,
along with relevant demographic and medical history information in order to examine the
association between and test hypotheses regarding suspected hazards and to estimate the risks
of developing aplastic anemia. The basic epidemiologic features of aplastic anemia were
described by characterizing these patients in terms of standard demographic variables, age,
race, sex, and medical history. The degree of association between viral hepatitis and the
development of aplastic anemia was estimated.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
Study Type
Observational
Condition
Blood Disease
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Start Date
September 1988
Completion Date
August 1994
Eligibility Criteria
No eligibility criteria
Gender
Male
Ages
N/A - 100 Years
Accepts Healthy Volunteers
No
Contacts
Paul Leaverton, ,
Administrative Informations
NCT ID
NCT00005682
Organization ID
3008
Secondary IDs
R01HL035068
Study Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Study Sponsor
Paul Leaverton, ,
Verification Date
May 2000