Brief Title
Aplastic Anemia Epidemiology: Incidence and Case-control
Brief Summary
To conduct incidence and case-control studies of aplastic anemia in metropolitan Bangkok, Thailand
Detailed Description
BACKGROUND: Aplastic anemia, a form of bone marrow failure, is a disease of largely unknown cause, except for the rare situations involving high doses of radiation. Many agents have been mentioned in case reports to be associated with the development of aplastic anemia and include drugs, chemicals, pesticides, radiation, and viral infection. Of these, chloramphenicol, phenylbutazone, and insecticides are most frequently reported. In the United States and other developed countries the disease prevalence is so low that too few cases occur to make an epidemiological study in a single city logistically feasible. The Bangkok hospitalization rate for aplastic anemia was sufficient to conduct a case-control study. Also, a study conducted in this locale provided information on drugs and chemicals not commonly used in developed countries. DESIGN NARRATIVE: All aplastic anemia cases in metropolitan Bangkok were located and verified in the forty hospitals that agreed to participate in the study. Incidence rates were calculated by age group and sex. In the case-control study, interviews were used to obtain comprehensive histories of drug, chemical, pesticide, radiation, viral infections, and other exposures, along with relevant demographic and medical history information in order to examine the association between and test hypotheses regarding suspected hazards and to estimate the risks of developing aplastic anemia. The basic epidemiologic features of aplastic anemia were described by characterizing these patients in terms of standard demographic variables, age, race, sex, and medical history. The degree of association between viral hepatitis and the development of aplastic anemia was estimated. The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Study Type
Observational
Condition
Blood Disease
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Start Date
September 1988
Completion Date
August 1994
Eligibility Criteria
No eligibility criteria
Gender
Male
Ages
N/A - 100 Years
Accepts Healthy Volunteers
No
Contacts
Paul Leaverton, ,
Administrative Informations
NCT ID
NCT00005682
Organization ID
3008
Secondary IDs
R01HL035068
Study Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Study Sponsor
Paul Leaverton, ,
Verification Date
May 2000