Brief Title
Value of Diffusion Weighted Magnetic Resonance Imaging in Detection of Recurrent Disease in Surgically Treated Cervical and Endometrial Cancer Patients
Official Title
Diagnostic Value of Diffusion Weighted Imaging in Detection of Recurrent Disease in Cervical and Endometrial Cancer Treated With Curative Surgery
Brief Summary
Endometrial and cervical cancers are one of the most common malignancies seen in females.
Identification of recurrent disease in early phases of treatment carries a primary importance
on the outcome of patients. Diffusion-weighted magnetic resonance imaging (DWI) is a new
technique recently started to be performed in body imaging and has potential ability to
detect recurrent disease. The aim of this study is to investigate the diagnostic impact of
DWI in detection of recurrent disease in patients treated with curative surgery in
endometrial and cervical cancer.
Detailed Description
Endometrial and cervical cancers are one of the most common malignancies seen in female
genital tract. Although, surgical resection is the treatment of choice for both, adjuvant or
neo-adjuvant chemotherapy or radiotherapy and curative radiotherapy are alternative treatment
options depending on the stage.
Identification of recurrent disease in early phases carries a primary importance on the
prognosis.
Diffusion-weighted MRI (DWI), a new technique recently started to be performed in body
imaging has potential ability to distinguish recurrent disease from normal tissue or
fibrosis. Our aim in this study is to investigate the diagnostic impact of DWI in detection
of recurrence rate in patients treated with curative surgery in endometrial and cervical
cancer.
All patients who had curative surgery due to endometrial or cervical cancer will be included
to the study. Patients will be examined with DWI in addition to routine sequences including
contrast enhanced dynamic studies. The sensitivity, specificity, accuracy as well as positive
and negative predictive values of the study will be investigated from the data derived from
DWI studies and will be correlated with data obtained by conventional radiologic, nuclear
imaging studies including PET-CT, as well as pathologic verifications during follow-up
period.
Study Type
Interventional
Primary Outcome
Investigation of the diagnostic value of DWI in detection of recurrence rate in patients treated with curative surgery in endometrial and cervical cancer.
Condition
Cervical Cancer
Intervention
Diffusion weighted MRI (DW- MRI)- Philips Achieva 3.0T X, Netherlands, 2011
Study Arms / Comparison Groups
Diffusion weighted imaging, Recurrence
Description:
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Device
Estimated Enrollment
100
Start Date
August 2012
Completion Date
February 2014
Primary Completion Date
August 2013
Eligibility Criteria
Inclusion Criteria:
- Pathologic diagnosis of cervical or endometrial cancer.
- Patients treated with curative surgery (hysterectomy)will be involved on a voluntary
basis.
Exclusion Criteria:
- Contraindications for MRI examination (cardiac pacemakers, metallic objects, cochlear
implants, claustrophobic patients)
Gender
Female
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
Gürsel Savcı, Prof., +905055873273, [email protected]
Location Countries
Turkey
Location Countries
Turkey
Administrative Informations
NCT ID
NCT01710085
Organization ID
KUAP(T)-2012/39
Responsible Party
Principal Investigator
Study Sponsor
Uludag University
Study Sponsor
Gürsel Savcı, Prof., Study Director, Uludag University Faculty of Medicine
Verification Date
October 2012