Brief Title
The Compatibility of Preoperative Endometrial Biopsies With Postoperative Final Pathology in Endometrial Cancer
Official Title
The Compatibility of Preoperative Endometrial Biopsies With Postoperative Final Pathology in Endometrial Cancer; Should Preoperative Pathology Samples of Patients Referred to a Tertiary Center be Re-evaluated?
Brief Summary
Although there are many studies comparing preoperative and postoperative histological
diagnoses in the literature, there are no studies evaluating the compatibility of
preoperative histological diagnoses obtained from different centers with postoperative
histological diagnoses.Therefore, in our study, we aimed to determine whether preoperative
pathological specimens need to be re-evaluated in the referenced hospitals by comparing the
compatibility of endometrial specimens in secondary care and tertiary centers with their
final pathologies.In our study, we aimed to reveal the under and overdiagnosis rates of the
preoperative histological diagnoses of our hospitals compared to the final pathology.
Detailed Description
Medical data of 960 patients diagnosed with endometrial cancer by endometrial biopsy between
2002 and 2016 were retrospectively analyzed. Of these patients, 41 were excluded from the
study due to non-surgical treatment, 254 patients having biopsy only in one center
preoperatively, and lack of medical data in 52 patients.The study included 613 patients who
had preoperative endometrial biopsy specimens evaluated by two different centers, diagnosed
with endometrial cancer and treated surgically. Our study was conducted in the gynecological
oncology department of our university after obtaining the approval of the ethics committee
numbered 430-2019.The clinicopathological characteristics of the patients were evaluated by
examining the hospital records of age, gravida, parity, BM (body mass index), menopausal
status and systemic diseases. Histopathological and clinical features of endometrial cancer
were reviewed.In this study, endometrial biopsy samples taken in the second stage state
hospital were re-evaluated by the gynecopathologist working at the university hospital and /
or the evaluation process was carried out in two steps by examining the repeated endometrial
biopsy sampling.Patients diagnosed with endometrial cancer were treated surgically in our
clinic. Endometrial sampling results based on uterine cancer risk groups; While
histologically endometrioid and nonendometrioid were evaluated in two groups, the greade1-2
(low risk), greade3 (high risk) of uterine cancer were evaluated in four groups as those
without malingnancy (benign and premaling lesions).By comparing these preoperative
histological diagnoses with postoperative surgical final pathology, the accuracy rates for
histological type and greade were determined. In addition, lower diagnosis, comorbidity and
higher diagnosis rates compared to final pathology were examined for two different centers.
Study Type
Observational
Primary Outcome
Comparison of endometrial sampling results performed in 2 different centers
Secondary Outcome
To reveal the rates of under and overdiagnosis of preoperative histological results
Condition
Endometrial Cancer Stage
Intervention
re-evaluation of endometrial biopsy samples by a gynecopathologist working at a university hospital
Study Arms / Comparison Groups
preoperative endometrial sampling result (secondary hospital)/1
Description: Endometrial biopsy samples taken at the stage 2 state hospital
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Diagnostic Test
Estimated Enrollment
960
Start Date
April 12, 2002
Completion Date
May 27, 2021
Primary Completion Date
April 24, 2021
Eligibility Criteria
Inclusion Criteria:
- Female patients aged 40-90 years diagnosed with endometrial cancer according to
endometrial sampling results
Exclusion Criteria:
- Lack of medical data
- Endometrial sampling in only one center
Gender
Female
Ages
40 Years - 90 Years
Accepts Healthy Volunteers
No
Contacts
Yusuf Cakmak, M.D, ,
Administrative Informations
NCT ID
NCT04917341
Organization ID
2020-12
Responsible Party
Principal Investigator
Study Sponsor
Batman Maternity and Child's Health Hospital
Collaborators
Eskisehir Osmangazi University
Study Sponsor
Yusuf Cakmak, M.D, Principal Investigator, Batman education and research hospital
Verification Date
June 2021