Brief Title
Transient ECG Changes in Patients With Acute Biliary Disease
Official Title
Transient ECG Changes in Patients With Acute Biliary Disease
Brief Summary
Background:
The importance of ischemic ECG changes including St segment elevation, ST segment depression
or T wave inversion that indicate myocardial ischemia are well established and require
appropriate investigation and treatment.
However, there is an abundance of clinical situation, with apparently ischemic ECG change not
indicate traditionally coronary artery related ischemia and therefore require prompt
recognition and treatment of underlying condition, that may be serious and life-threatened.
For example of such conditions are pericarditis, myocarditis, aortic dissection, electrolyte
abnormalities, intracranial hemorrhage and hypothermia.
Together with them, an ECG ST segment changes may appeared in abdominal serious illness such
as pancreatitis and cholecystitis(17,18,19,20,23). Whereas in pancreatitis various vasoactive
and toxic for myocardium substances released, the cause of ST segment changes in
cholecystitis are discussed and includes tachycardia , vagal reflexes, changed in plasma
rennin activity resulted by distension of the gallbladder.
The certain proportion of the patients with ECG changes actually didn't have coronary artery
disease(9,15) or other acute cardiac condition and therefore require treatment of the
underlie illness only without spend the time for cardiac investigation or special
treatment(1,3,4,7,8). Some kind of treatment may be even harmful for the patients with
abdominal illness such as thrombolytic, anticoagulant, aggressive antiaggregant therapy or
unnecessary cardiac catheterization.
In the medical literature the investigators found some case reports and works about the ECG
changes in acute biliary disease in patient with knowing cardiac disease and without it, but
actually incidence of ECG changes that suggest but not represent an acute coronary illness
isn't knowing.
Therefore this is necessary to investigate actually incidence of ECG changes that mimic acute
coronary syndrome in acute cholecystitis and acute biliary disease and determined clinical
and laboratory characteristics that helps to differentiate this patients.
Study Type
Observational
Condition
Acute Cholecystitis
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
100
Start Date
November 2012
Completion Date
May 2014
Primary Completion Date
November 2013
Eligibility Criteria
Inclusion Criteria:
1. Patients from age 18 and up to 75years old.
2. Causes of admission to the ED are acute cholecystitis, biliary colic, acute
cholangitis
3. The patient is willing to participate in the study and is able to sign an informed
consent form.
Exclusion Criteria:
1. Elective hospitalization with known and not acute condition.
2. Inability to give inform consent .
3. Sepsis as complication of illness.
4. Chronic ECG changes known by medical history.
5. Knowing history of IHD.
6. Previous cardiac catheterization with documented stenosis of at least 1 major coronary
artery equal or more 50%.
Gender
All
Ages
18 Years - 75 Years
Accepts Healthy Volunteers
No
Contacts
, ,
Location Countries
Israel
Location Countries
Israel
Administrative Informations
NCT ID
NCT01706068
Organization ID
ECGCTIL
Responsible Party
Principal Investigator
Study Sponsor
Ziv Hospital
Study Sponsor
, ,
Verification Date
October 2012