Brief Title
Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia
Brief Summary
Many anesthesiologists use the Remifentanil for reducing a surgical pain and stabilizing a
vital sign. However, this drug induce postoperative hyperalgesia. Nowadays, many studies
report that low-dose Ketamine prevents the opioid-induces hyperalgesia. Nefopam,which is
non-opioid analgesic, has similar mechanism with Ketamine. It will be helpful for
postoperative pain control, and reduce the needs of opioid.
Study Phase
Phase 4
Study Type
Interventional
Primary Outcome
analgesic requirement
Secondary Outcome
analgesic requirement
Condition
Cholecystitis
Intervention
Nefopam
Study Arms / Comparison Groups
Nefopam
Description: The generic name is 'ACUPAN'. It is infused during operation. A induction dose is 0.3mg/Kg. A maintenance dose is 65 mcg/kg/hr
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
60
Start Date
March 2015
Primary Completion Date
December 2015
Eligibility Criteria
Inclusion Criteria:
- patient who scheduled laparoscopic cholecystectomy under general anesthesia
- American Society of Anesthesiologist(ASA) class I or II
- adult patient (age 20 - 65)
Exclusion Criteria:
- patient who has liver disease
- patient who has kidney disease
- patient who has diabetes mellitus(DM) or heart disease
- patient who takes opioid or beta-blocker
- patient who has airway disease
- patient who has allergy with the drug
Gender
All
Ages
20 Years - 65 Years
Contacts
, +82-02-829-5230, [email protected]
Location Countries
Korea, Republic of
Location Countries
Korea, Republic of
Administrative Informations
NCT ID
NCT02493231
Organization ID
2014-10-133
Responsible Party
Principal Investigator
Study Sponsor
Hallym University Kangnam Sacred Heart Hospital
Study Sponsor
, ,
Verification Date
August 2015