Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia

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Brief Title

Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia

Brief Summary

      Many anesthesiologists use the Remifentanil for reducing a surgical pain and stabilizing a
      vital sign. However, this drug induce postoperative hyperalgesia. Nowadays, many studies
      report that low-dose Ketamine prevents the opioid-induces hyperalgesia. Nefopam,which is
      non-opioid analgesic, has similar mechanism with Ketamine. It will be helpful for
      postoperative pain control, and reduce the needs of opioid.

Study Phase

Phase 4

Study Type

Interventional

Primary Outcome

analgesic requirement

Secondary Outcome

 analgesic requirement

Condition

Cholecystitis

Intervention

Nefopam

Study Arms / Comparison Groups

 Nefopam
Description:  The generic name is 'ACUPAN'. It is infused during operation. A induction dose is 0.3mg/Kg. A maintenance dose is 65 mcg/kg/hr

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Drug

Estimated Enrollment

60

Start Date

March 2015

Primary Completion Date

December 2015

Eligibility Criteria

        Inclusion Criteria:

          -  patient who scheduled laparoscopic cholecystectomy under general anesthesia

          -  American Society of Anesthesiologist(ASA) class I or II

          -  adult patient (age 20 - 65)

        Exclusion Criteria:

          -  patient who has liver disease

          -  patient who has kidney disease

          -  patient who has diabetes mellitus(DM) or heart disease

          -  patient who takes opioid or beta-blocker

          -  patient who has airway disease

          -  patient who has allergy with the drug

Gender

All

Ages

20 Years - 65 Years

Contacts

, +82-02-829-5230, [email protected]

Location Countries

Korea, Republic of

Location Countries

Korea, Republic of

Administrative Informations

NCT ID

NCT02493231

Organization ID

2014-10-133

Responsible Party

Principal Investigator

Study Sponsor

Hallym University Kangnam Sacred Heart Hospital

Study Sponsor

, ,

Verification Date

August 2015