Is it Fair to Use Antibiotics After Laparoscopic Cholecystectomy for the Patients With Acutely Inflamed Gallbladder?
Is it Fair to Use Antibiotics After Laparoscopic Cholecystectomy for the Patients With Acutely Inflamed Gallbladder?; a Multicenter Randomized Controlled Trial
During the laparoscopic cholecystectomy for acute cholecystitis, most surgeons routinely use the postoperative antibiotics after surgery. However, there is no consensus regarding the actual need of postoperative antibiotics in these cases and the use of postoperative antibiotics remains controversial. Investigators will compare the surgical outcomes after laparoscopic cholecystectomy to the patients who has no evidence of systemic infection, according to the usage of postoperative antibiotics or not. The investigators expect that the routine use of postoperative antibiotics after laparoscopic cholecystectomy for acute cholecystitis gallbladder will have no effects on the postoperative morbidity.
Primary outcome of this study is the confirmation of safety in the cases of acute cholecystitis without postoperative antibiotics usage after laparoscopic cholecystectomy. For this purpose, the investigators compare the surgical infectious outcomes including the wound infection or abdominal infections according to the usage of postoperative antibiotics after laparoscopic cholecystectomy. Secondary outcome of this study is the confirmation of efficacy according to skip the use of postoperative antibiotics after laparoscopic cholecystectomy. The investigators estimate the efficacy using the comparing the outcomes such as duration of hospitalization according to the use of postoperative antibiotics or not.
Number of Participants With Infectious Postoperative Complications
Duration of Hospitalization
Study Arms / Comparison Groups
Group A (cephalosporin)
Description: During the period of hospitalization, intake of active drug ('pacetin', 2nd generation cephalosporin). 3 g per day divided into 3 times via intravenous route until the day of discharge. After discharge, oral intakes of 500mg each (1 pill of cefaclor, the 2nd generation cephalosporin every 12 hrs) for three days.
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Primary Completion Date
Inclusion Criteria: - grade I Tokyo guideline for acute cholecystitis - grade II Tokyo guideline for acute cholecystitis without the evidence of gallbladder perforation Exclusion Criteria: - chronic cholecystitis - gallbladder polyp or gallbladder cancer - the patient who underwent reduced port surgery - the patient who underwent common bile duct exploration during the operation - the patient who underwent concurrent operation - the patient who had past history of upper abdominal surgery - the patient who had a immunodeficiency state - the case which had a suspicion of delayed bile leakage - the case which had a incomplete cystic duct ligation - the patient who underwent open conversion surgery during the operation - the patient who had a high risk of bleeding
18 Years - N/A
Accepts Healthy Volunteers
Taeho Hong, ,
Korea, Republic of
Korea, Republic of
Incheon St.Mary's Hospital
Taeho Hong, Principal Investigator, Seoul St. Mary's Hospital