Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line

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Tongue neoplasm
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Brief Title

Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line

Official Title

Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line: In Vitro Study

Brief Summary

      In vitro study to examine whether luteolin and nano-luteolin exert an inhibitory effect on
      tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if
      nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell
      carcinoma cell line.

Detailed Description

      This study is conducted to examine whether luteolin and nano-luteolin exert an inhibitory
      effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if
      nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell
      carcinoma cell line. The primary outcome is apoptosis, while the secondary outcome is cell
      viability.

Study Phase

Early Phase 1

Study Type

Interventional

Primary Outcome

gene expression of Caspase 3 to detect apoptosis

Secondary Outcome

 cell viability

Condition

Tongue Neoplasms

Intervention

luteolin

Study Arms / Comparison Groups

 luteolin
Description:  a natural extract derived flavinoids

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Drug

Estimated Enrollment

4

Start Date

November 1, 2017

Completion Date

April 1, 2019

Primary Completion Date

September 1, 2018

Eligibility Criteria

        Inclusion Criteria:

          -  Squamous cell carcinoma cell lines (OSCC, TSCC and HNSCC).

          -  Luteolin 5,7,3',4'-tetrahydroxy-flavone (MeSH term).

          -  Application of luteolin as a chemotherapeutic drug.

        Exclusion Criteria:

          -  Any cancer cell line other than OSCC, TSCC and HNSCC cell lines.

          -  Luteolin glycosides.

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Ahmed Elkhadem, PhD, 002 01119777824, [email protected]

Administrative Informations

NCT ID

NCT03288298

Organization ID

CEBD-CU-2017-09-23

Responsible Party

Principal Investigator

Study Sponsor

Cairo University

Study Sponsor

Ahmed Elkhadem, PhD, Study Chair, Center for Evidence Based Dentistry

Verification Date

September 2017