Brief Title
Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line
Official Title
Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line: In Vitro Study
Brief Summary
In vitro study to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line.
Detailed Description
This study is conducted to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line. The primary outcome is apoptosis, while the secondary outcome is cell viability.
Study Phase
Early Phase 1
Study Type
Interventional
Primary Outcome
gene expression of Caspase 3 to detect apoptosis
Secondary Outcome
cell viability
Condition
Tongue Neoplasms
Intervention
luteolin
Study Arms / Comparison Groups
luteolin
Description: a natural extract derived flavinoids
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Drug
Estimated Enrollment
4
Start Date
November 1, 2017
Completion Date
April 1, 2019
Primary Completion Date
September 1, 2018
Eligibility Criteria
Inclusion Criteria: - Squamous cell carcinoma cell lines (OSCC, TSCC and HNSCC). - Luteolin 5,7,3',4'-tetrahydroxy-flavone (MeSH term). - Application of luteolin as a chemotherapeutic drug. Exclusion Criteria: - Any cancer cell line other than OSCC, TSCC and HNSCC cell lines. - Luteolin glycosides.
Gender
All
Ages
N/A - N/A
Accepts Healthy Volunteers
No
Contacts
Ahmed Elkhadem, PhD, 002 01119777824, [email protected]
Administrative Informations
NCT ID
NCT03288298
Organization ID
CEBD-CU-2017-09-23
Responsible Party
Principal Investigator
Study Sponsor
Cairo University
Study Sponsor
Ahmed Elkhadem, PhD, Study Chair, Center for Evidence Based Dentistry
Verification Date
September 2017