The Role of microRNA-29b in the Oral Squamous Cell Carcinoma

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Brief Title

The Role of microRNA-29b in the Oral Squamous Cell Carcinoma

Official Title

The Role of microRNA-29b in the Oral Squamous Cell Carcinoma

Brief Summary

      The Role of microRNA-29b in the Oral Squamous Cell Carcinoma
    

Detailed Description

      To find out if there is prognostic value which to the performance of microRNA-29b of oral
      cancer in Taiwan and provide some reference for future treatment.

      We anticipate to enroll 100 persons with oral cancer and collect the tissue which was stained
      for pathological sections over a 3 year period.

      We also collect the blood and saliva samples from patients and the results along with
      patient-specific information such as tumor phases, tumor size, lymph node metastasis, cancer
      metastasis, prognosis and betel nut chewing, smoking and drinking habits and other parameters
      are statistically analyzed.
    


Study Type

Observational [Patient Registry]


Primary Outcome

microRNA-29b


Condition

Oral Cancer


Study Arms / Comparison Groups

 Oral cancer
Description:  Subjects who suffer from oral cancer.
Subjects must:
Should have a blood exam (20ml/each time) before the surgery and 3 months after the surgery.
In the case the disease recurs after the surgery, subjects need to receive the surgery again and take another blood exam before the surgery and 3 months after the surgery.
Before the surgery site staff must:
Collect subjects' saliva once a day (in the morning before breakfast) for 3 consecutive days.
Collect a 0.5x0.5Cm2 tissue sample of the tumor during the surgery.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

100

Start Date

January 2014


Primary Completion Date

December 2014

Eligibility Criteria

        Inclusion Criteria:

          -  Cancer of the oral cavity.

        Exclusion Criteria:

          -  pregnant woman

          -  refuse the surgery
      

Gender

All

Ages

20 Years - 80 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Shin-Jung Cheng, DDS, MS, PhD, +886 2 29251733, [email protected]

Location Countries

Taiwan

Location Countries

Taiwan

Administrative Informations


NCT ID

NCT02009852

Organization ID

201309076RIN


Responsible Party

Sponsor

Study Sponsor

National Taiwan University Hospital


Study Sponsor

Shin-Jung Cheng, DDS, MS, PhD, Principal Investigator, 


Verification Date

December 2013