The Link Between Periodontitis, Smoking and Oral Cancer

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Tongue neoplasm
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Brief Title

The Link Between Periodontitis, Smoking and Oral Cancer

Official Title

Analysis of the Link Between Periodontitis, Smoking and Oral Cancer: Cohort Study

Brief Summary

      Periodontitis is a widely prevalent disease worldwide that has serious public health
      consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively
      affects chewing causing functional disability; and esthetics causing social impairment.
      Consequently, periodontitis may end up causing marked impairment of the quality of life of
      the affected patients, impairment of general health and increasing the dental care costs
      significantly.

      Changes in the oral mucosa arise by primary products resulting from tissue breakdown due to
      gingivitis. It then triggers the host cells to produce proteinases that mediate loss of
      marginal periodontal ligaments, apical migration of the junctional epithelium and apical
      spread of bacterial biofilm.

      Therefore, this research aims to identify the risk of smoking to both periodontitis and oral
      cancer, and the risk of periodontitis to oral cancer.

Study Type

Observational

Primary Outcome

Periodontitis

Secondary Outcome

 Oral cancer

Condition

Chronic Periodontitis

Intervention

biopsy for oral cancer

Study Arms / Comparison Groups

 Smokers
Description:

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status

Diagnostic Test

Estimated Enrollment

200

Start Date

August 12, 2021

Completion Date

January 30, 2032

Primary Completion Date

October 12, 2031

Eligibility Criteria

        Inclusion Criteria:

          -  Patients 18 years or older.

        Exclusion Criteria:

          -  Patients with any systemic diseases.

          -  Pregnant females.

          -  Handicapped and mentally retarded patients.

          -  Patients undergoing radiotherapy.

          -  Patients having oral cancer

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

, 01001874257, [email protected]

Location Countries

Egypt

Location Countries

Egypt

Administrative Informations

NCT ID

NCT04047212

Organization ID

P12

Responsible Party

Principal Investigator

Study Sponsor

Cairo University

Study Sponsor

, ,

Verification Date

June 2021