Symptoms and Mechanisms of Child Psychiatric Disorders

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Brief Title

Symptoms and Mechanisms of Child Psychiatric Disorders

Official Title

Associated Symptoms, Underlying Mechanisms and Parental Factors of Child Psychiatric Disorders With Focus on Severe Irritability.

Brief Summary

      In this study the investigators will examine psychiatric symptoms, central neurocognitive
      functions, parental stress and attachment styles, and biological factors that can give new
      knowledge about some of the mechanisms present in children referred to outpatient psychiatric
      clinics. A specific focus will be given to children suffering from severe irritability.
    

Detailed Description

      In this study the investigators will examine psychiatric symptoms, central neurocognitive
      functions, parental stress and attachment styles, and biological factors that can give new
      knowledge about some of the mechanisms present in children referred to outpatient psychiatric
      service. A specific focus will be given to children suffering from severe irritability making
      problems at home, in school, and/or with peers.

      Disruptive Mood Dysregulation Disorder (DMDD) is characterized by chronic and severe
      irritability and anger in children. DMDD understood as severe or clinical irritability can be
      regarded as laying above a certain threshold on a irritability continuum. Due to DMDD being a
      relatively new and debated diagnosis there is an urgent need to gain better understanding of
      the underlying mechanisms of severe irritability in children.

      This study will explore emotion and behavior symptoms, neuropsychological functions
      (including social perception), perceived parental stress and attachment styles, and cortisol
      levels of children and their mothers, in children referred to outpatient psychiatric service
      including children with severe irritability. Parents of children 6 to 12 years will be
      informed and asked to participate.

      The work on severe irritability will be divided into six main areas:

        1. Severe irritability in a Norwegian clinical population: prevalence, comorbidity and
           associated difficulties

        2. Social and emotional understanding in severe irritability in children

        3. Executive function in severe irritability in children

        4. Stress response in severe irritability in children

        5. Parental stress and attachment style in parents of severe irritability in children

        6. DMDD: An affective or conduct disorder? Comparing anxiety and depressive symptoms
    


Study Type

Observational [Patient Registry]


Primary Outcome

Social Perception by task performance: Affect Recognition


Condition

Disruptive Mood Dysregulation Disorder


Study Arms / Comparison Groups

 Children referred to outpatient clinic
Description:  Diagnostic interview (Schedule for Affective Disorders and Schizophrenia (K-SADS) cf. Diagnostic and Statistical Manual of Mental Disorders (DSM-5)) with parents. Diagnostic groups/cohorts (e.g., DMDD, ADHD, Oppositional Defiant Disorder) will be based on the diagnoses given cf. K-SADS.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

200

Start Date

June 26, 2020

Completion Date

December 2023

Primary Completion Date

December 2022

Eligibility Criteria

        Inclusion Criteria:

          -  Referred to outpatient psychiatric service

          -  Intelligence quotient (IQ) within normal range

          -  Child and parents: Good enough understanding of Norwegian language to give valid
             answers in interview and tests.

          -  Clarified care situation

        Exclusion Criteria:

          -  IQ below normal range

          -  Child and parents: Not good enough understanding of Norwegian language to give valid
             answers in interview and tests

          -  Unclarified care situation
      

Gender

All

Ages

6 Years - 12 Years

Accepts Healthy Volunteers

No

Contacts

Pål Zeiner, PhD, +4793264023, [email protected]

Location Countries

Norway

Location Countries

Norway

Administrative Informations


NCT ID

NCT05049356

Organization ID

2017/135


Responsible Party

Principal Investigator

Study Sponsor

Oslo University Hospital

Collaborators

 Linkoeping University

Study Sponsor

Pål Zeiner, PhD, Study Director, Head of Child Psychiatric Research at Oslo University Hospital


Verification Date

September 2021